The Reversibility of Heparin’s Effect on Trabecular Thickness, Number, and Separation
| . | Trabecular Width (μm) . | Trabecular No. (#/mm2) . | Trabecular Separation (μm) . |
|---|---|---|---|
| Baseline | 107.7 ± 2.7 | 9.6 ± 0.2 | 256.4 ± 6.2 |
| Day 28 | |||
| Control | 104.4 ± 1.7 | 9.8 ± 0.4 | 261.6 ± 9.8 |
| Heparin (0.5 U/g) | 85.4 ± 2.7* | 7.1 ± 0.4* | 282.2 ± 14.5* |
| Heparin (1.0 U/g) | 73.7 ± 3.3* | 7.5 ± 0.3* | 296.8 ± 12.4* |
| Day 56 | |||
| Control | 104.4 ± 1.7 | 9.8 ± 0.4 | 261.6 ± 9.8 |
| Heparin (0.5 U/g) | 84.5 ± 7.5*,† | 7.3 ± 0.5*,† | 279.5 ± 31.0*,† |
| Heparin (1.0 U/g) | 73.7 ± 1.7*,† | 6.8 ± 0.7*,† | 313.6 ± 24.2*,† |
| . | Trabecular Width (μm) . | Trabecular No. (#/mm2) . | Trabecular Separation (μm) . |
|---|---|---|---|
| Baseline | 107.7 ± 2.7 | 9.6 ± 0.2 | 256.4 ± 6.2 |
| Day 28 | |||
| Control | 104.4 ± 1.7 | 9.8 ± 0.4 | 261.6 ± 9.8 |
| Heparin (0.5 U/g) | 85.4 ± 2.7* | 7.1 ± 0.4* | 282.2 ± 14.5* |
| Heparin (1.0 U/g) | 73.7 ± 3.3* | 7.5 ± 0.3* | 296.8 ± 12.4* |
| Day 56 | |||
| Control | 104.4 ± 1.7 | 9.8 ± 0.4 | 261.6 ± 9.8 |
| Heparin (0.5 U/g) | 84.5 ± 7.5*,† | 7.3 ± 0.5*,† | 279.5 ± 31.0*,† |
| Heparin (1.0 U/g) | 73.7 ± 1.7*,† | 6.8 ± 0.7*,† | 313.6 ± 24.2*,† |
Rats were injected daily with vehicle alone or unfractionated heparin as described in Materials and Methods. On days 28 and 56, rats were exsanguinated and their right femurs removed for histologic examination. The region extending from the epiphyseal growth plate and including the entire metaphysis was analyzed for (1) trabecular width, (2) trabecular number, and (3) trabecular separation. Data are expressed as mean ± SEM.
P < .005 when compared with either baseline or control values.
P > .05 when compared with values obtained from heparin-treated animals at day 28.