Table 3.

Cytotoxic Activity of +/+, mi/mi, and tg/tg CMCs to YAC-1 Cells

E/T Ratio Specific51Cr Release (%)*
+/+ CMCsmi/mi CMCs tg/tg CMCs+/+ Spleen Cells
50  <0.1  <0.1  <0.1 50.8 ± 2.4  
100  13.9 ± 0.1 <0.1 12.0 ± 0.6 57.3 ± 3.8  
250  21.1 ± 2.8 <0.1  19.0 ± 1.9 NE 
E/T Ratio Specific51Cr Release (%)*
+/+ CMCsmi/mi CMCs tg/tg CMCs+/+ Spleen Cells
50  <0.1  <0.1  <0.1 50.8 ± 2.4  
100  13.9 ± 0.1 <0.1 12.0 ± 0.6 57.3 ± 3.8  
250  21.1 ± 2.8 <0.1  19.0 ± 1.9 NE 

E/T ratio is the ratio of CMCs or spleen cells to YAC-1 cells.

Abbreviation: NE, not examined.

*

Means ± SE of three experiments.

P < .01 by t-test when compared with the value ofmi/mi CMCs.

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