Table 3.

Direct Killing of Target Cells by HO-1

%Specific 51Cr Release From Target Cells
51Cr-Labeled Auto LCL51Cr-Labeled DR53 (−) LCL51Cr-Labeled Auto LCL + Unlabeled DR53 (−) LCL3-15051Cr-Labeled DR53 (−) LCL + Unlabeled Auto LCL3-151
61.3  −3.6  61.6  1.1 
%Specific 51Cr Release From Target Cells
51Cr-Labeled Auto LCL51Cr-Labeled DR53 (−) LCL51Cr-Labeled Auto LCL + Unlabeled DR53 (−) LCL3-15051Cr-Labeled DR53 (−) LCL + Unlabeled Auto LCL3-151
61.3  −3.6  61.6  1.1 
F3-150

The 51Cr release assay was performed in the presence of 51Cr-labeled DEK-CAN peptide-loaded autologous LCL and unlabeled peptide-loaded HLA-DR53 allogeneic LCL.

F3-151

The 51Cr release assay was performed in the presence of51Cr-labeled DEK-CAN peptide-loaded HLA-DR53allogeneic LCL and unlabeled peptide-loaded autologous LCL.

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