Pathologic Findings and CAS 100 Analysis of Degree of Apoptosis in the Splenic Red Pulp and Arterioles and Fas Expression in Splenic Red Pulp of TTP and Control Patients
| Patient No. . | Arteriolar Thrombi . | Histopathology . | Apoptosis (% TUNEL positivity) . | Fas Expression . | |||
|---|---|---|---|---|---|---|---|
| SED . | PAF . | Germinal Centers . | Red Pulp . | Arterioles . | Red Pulp . | ||
| TTP-1 | + | + | − | − | 7.3% | 0.0% | 9.2% |
| TTP-2 | + | + | − | − | 1.2% | 0.0% | 18.7% |
| TTP-3 | + | + | − | − | 0.0% | 0.0% | 3.7% |
| TTP-4 | − | + | − | +++ | 4.3% | 4.1% | NA |
| TTP-5 | + | + | − | + | 0.1% | 0.0% | 8.6% |
| TTP-6 | + | + | − | − | 4.8% | 0.0% | 16.5% |
| TTP-7 | − | + | + | +++ | 0.0% | 0.0% | 1.5% |
| TTP-8 | − | + | − | − | 12.8% | 2.0% | 5.3% |
| Control-1 | − | + | − | + | 0.0% | 0.0% | 5.4% |
| Control-2 | − | + | − | + | 0.0% | 0.0% | NA |
| Control-3* | − | − | + | ++ | 1.0% | 0.0% | 3.6% |
| Control-4 | − | − | − | + | 0.5% | 0.0% | 4.2% |
| Control-5* | − | − | − | +++ | 0.0% | 0.0% | 14.4% |
| Control-6 | − | + | − | +++ | 0.0% | 0.0% | 2.2% |
| Patient No. . | Arteriolar Thrombi . | Histopathology . | Apoptosis (% TUNEL positivity) . | Fas Expression . | |||
|---|---|---|---|---|---|---|---|
| SED . | PAF . | Germinal Centers . | Red Pulp . | Arterioles . | Red Pulp . | ||
| TTP-1 | + | + | − | − | 7.3% | 0.0% | 9.2% |
| TTP-2 | + | + | − | − | 1.2% | 0.0% | 18.7% |
| TTP-3 | + | + | − | − | 0.0% | 0.0% | 3.7% |
| TTP-4 | − | + | − | +++ | 4.3% | 4.1% | NA |
| TTP-5 | + | + | − | + | 0.1% | 0.0% | 8.6% |
| TTP-6 | + | + | − | − | 4.8% | 0.0% | 16.5% |
| TTP-7 | − | + | + | +++ | 0.0% | 0.0% | 1.5% |
| TTP-8 | − | + | − | − | 12.8% | 2.0% | 5.3% |
| Control-1 | − | + | − | + | 0.0% | 0.0% | 5.4% |
| Control-2 | − | + | − | + | 0.0% | 0.0% | NA |
| Control-3* | − | − | + | ++ | 1.0% | 0.0% | 3.6% |
| Control-4 | − | − | − | + | 0.5% | 0.0% | 4.2% |
| Control-5* | − | − | − | +++ | 0.0% | 0.0% | 14.4% |
| Control-6 | − | + | − | +++ | 0.0% | 0.0% | 2.2% |
Germinal centers are graded from rare (+) to occasional (++) to many (+++).
Abbreviations: SED, subendothelial deposit; PAF, periarterial concentric fibrosis; NA, not available.
Control-3 and Control-5 are ITP specimens.