Clinical and Biologic Data for the MM and Primary PCL Cases
| Parameter . | MM (n = 664) . | PCL (n = 26) . | P . |
|---|---|---|---|
| Age ≥65 years (median) | 65.0% (68 ± 10) | 50.0% (66 ± 10) | .12216 |
| Male | 53% | 46% | .49355 |
| ECOG ≥2 | 33% | 58% | .01993 |
| Extramedullary involvement | 4% | 23% | .01407 |
| Bone scale ≥2 | 67% | 48% | .17767 |
| Hemoglobin <8.5 g/dL | 31% (10.1 ± 2.7) | 54% (8.2 ± 2.3) | .01451 |
| Platelets <100 × 109/L | 9% (209 ± 83) | 48% (123 ± 88) | <.00001 |
| Stage III | 59% | 92% | .00093 |
| BM PCs ≥40% | 43% | 92% | <.00001 |
| LDH ≥460 U/L | 9% | 48% | <.00001 |
| Albumin <3.5 g/dL | 46% | 52% | .58077 |
| Type of monoclonal component | |||
| IgG | 55% | 54% | .00027 |
| IgA | 30% | 4% | |
| IgD | 1% | 8% | |
| Bence Jones | 13% | 31% | |
| Nonsecretory | 1% | 4% | |
| Monoclonal proteinuria | 40% | 68% | .00068 |
| Creatinine ≥2 mg/dL | 21% | 44% | .00634 |
| Calcium ≥11.0 mg/dL | 20% | 48% | .00071 |
| β2-Microglobulin ≥6 mg/mL | 27% | 65% | .00012 |
| C-reactive protein ≤6 mg/dL | 18% | 61% | .00015 |
| S-phase PCs ≥3% | 32% | 71% | <.00001 |
| S-phase residual BM cells <4.5% | 26% | 83% | <.00001 |
| Global response | 63% | 38% | .01330 |
| OR and complete response | 40% | 29% | .27427 |
| Parameter . | MM (n = 664) . | PCL (n = 26) . | P . |
|---|---|---|---|
| Age ≥65 years (median) | 65.0% (68 ± 10) | 50.0% (66 ± 10) | .12216 |
| Male | 53% | 46% | .49355 |
| ECOG ≥2 | 33% | 58% | .01993 |
| Extramedullary involvement | 4% | 23% | .01407 |
| Bone scale ≥2 | 67% | 48% | .17767 |
| Hemoglobin <8.5 g/dL | 31% (10.1 ± 2.7) | 54% (8.2 ± 2.3) | .01451 |
| Platelets <100 × 109/L | 9% (209 ± 83) | 48% (123 ± 88) | <.00001 |
| Stage III | 59% | 92% | .00093 |
| BM PCs ≥40% | 43% | 92% | <.00001 |
| LDH ≥460 U/L | 9% | 48% | <.00001 |
| Albumin <3.5 g/dL | 46% | 52% | .58077 |
| Type of monoclonal component | |||
| IgG | 55% | 54% | .00027 |
| IgA | 30% | 4% | |
| IgD | 1% | 8% | |
| Bence Jones | 13% | 31% | |
| Nonsecretory | 1% | 4% | |
| Monoclonal proteinuria | 40% | 68% | .00068 |
| Creatinine ≥2 mg/dL | 21% | 44% | .00634 |
| Calcium ≥11.0 mg/dL | 20% | 48% | .00071 |
| β2-Microglobulin ≥6 mg/mL | 27% | 65% | .00012 |
| C-reactive protein ≤6 mg/dL | 18% | 61% | .00015 |
| S-phase PCs ≥3% | 32% | 71% | <.00001 |
| S-phase residual BM cells <4.5% | 26% | 83% | <.00001 |
| Global response | 63% | 38% | .01330 |
| OR and complete response | 40% | 29% | .27427 |