Distribution of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genotypes in ALL Cases and Controls
| Locus . | Cases . | Controls . | |||
|---|---|---|---|---|---|
| Allele . | Genotype† . | n‡ . | No.2-153(%) . | n‡ . | No.2-153 (%) . |
| CYP1A1*2A | −/− | 170 | 137 (80.6) | 299 | 264 (88.3) |
| −/+ | 32 (18.8) | 33 (11.0) | |||
| +/+ | 1 (0.6) | 2 (0.7) | |||
| CYP1A1*2B | −/− | 170 | 158 (92.9) | 299 | 275 (92.0) |
| −/+ | 11 (6.5) | 24 (8.0) | |||
| +/+ | 1 (0.6) | 0 (0.0) | |||
| CYP1A1*4 | −/− | 177 | 167 (94.4) | 295 | 267 (90.5) |
| −/+ | 8 (4.5) | 26 (8.8) | |||
| +/+ | 2 (1.1) | 2 (0.7) | |||
| CYP2D6*3 | −/− | 167 | 159 (95.2) | 302 | 289 (95.7) |
| −/+ | 5 (3.0) | 12 (4.0) | |||
| +/+ | 3 (1.8) | 1 (0.3) | |||
| CYP2D6*4 | −/− | 176 | 113 (64.2) | 302 | 207 (68.5) |
| −/+ | 55 (31.3) | 86 (28.5) | |||
| +/+ | 8 (4.5) | 9 (3.0) | |||
| CYP2D6 | PM | 165 | 11 (6.7) | 299 | 11 (3.7) |
| GSTM1 | Present | 174 | 61 (35.1) | 304 | 148 (48.7) |
| Null | 113 (64.9) | 156 (51.3) | |||
| GSTT1 | Present | 176 | 148 (84.1) | 274 | 227 (82.8) |
| Null | 28 (15.9) | 47 (17.2) | |||
| Locus . | Cases . | Controls . | |||
|---|---|---|---|---|---|
| Allele . | Genotype† . | n‡ . | No.2-153(%) . | n‡ . | No.2-153 (%) . |
| CYP1A1*2A | −/− | 170 | 137 (80.6) | 299 | 264 (88.3) |
| −/+ | 32 (18.8) | 33 (11.0) | |||
| +/+ | 1 (0.6) | 2 (0.7) | |||
| CYP1A1*2B | −/− | 170 | 158 (92.9) | 299 | 275 (92.0) |
| −/+ | 11 (6.5) | 24 (8.0) | |||
| +/+ | 1 (0.6) | 0 (0.0) | |||
| CYP1A1*4 | −/− | 177 | 167 (94.4) | 295 | 267 (90.5) |
| −/+ | 8 (4.5) | 26 (8.8) | |||
| +/+ | 2 (1.1) | 2 (0.7) | |||
| CYP2D6*3 | −/− | 167 | 159 (95.2) | 302 | 289 (95.7) |
| −/+ | 5 (3.0) | 12 (4.0) | |||
| +/+ | 3 (1.8) | 1 (0.3) | |||
| CYP2D6*4 | −/− | 176 | 113 (64.2) | 302 | 207 (68.5) |
| −/+ | 55 (31.3) | 86 (28.5) | |||
| +/+ | 8 (4.5) | 9 (3.0) | |||
| CYP2D6 | PM | 165 | 11 (6.7) | 299 | 11 (3.7) |
| GSTM1 | Present | 174 | 61 (35.1) | 304 | 148 (48.7) |
| Null | 113 (64.9) | 156 (51.3) | |||
| GSTT1 | Present | 176 | 148 (84.1) | 274 | 227 (82.8) |
| Null | 28 (15.9) | 47 (17.2) | |||
−/−, absence of mutant allele; −/+, heterozygous; +/+, homozygous for mutant allele; PM, poor metabolizer, ie, homozygous and combined heterozygous for alleles *3 and *4; present, carrier of at least one wild-type allele; null, homozygous deletion.
Total number of individuals tested.
Number of individuals with a given genotype.