Combined Effects of GSTM1 Null Genotype and CYP1A1*2A Allele in Childhood ALL Risk
| Genotype at Risk . | GSTM1 . | CYP1A1*2A . | Cases (n = 166) . | Controls (n = 299) . | OR (95% CI) . |
|---|---|---|---|---|---|
| None | Present | −/− | 49 | 126 | 1.0 (referent) |
| One | Null | −/− | 84 | 138 | 1.6 (1.0-2.4) |
| Present | +/+, −/+ | 12 | 19 | 1.6 (0.7-3.6) | |
| Two | Null | +/+, −/+ | 21 | 16 | 3.3 (1.6-6.9)4-151 |
| Genotype at Risk . | GSTM1 . | CYP1A1*2A . | Cases (n = 166) . | Controls (n = 299) . | OR (95% CI) . |
|---|---|---|---|---|---|
| None | Present | −/− | 49 | 126 | 1.0 (referent) |
| One | Null | −/− | 84 | 138 | 1.6 (1.0-2.4) |
| Present | +/+, −/+ | 12 | 19 | 1.6 (0.7-3.6) | |
| Two | Null | +/+, −/+ | 21 | 16 | 3.3 (1.6-6.9)4-151 |
Abbreviations: OR, crude odds ratio; CI, confidence interval.
P = .002.