HIV Replication Is Required for MCP-1 Induction in MDM
| . | MCP-1 (ng/mL) . | |||
|---|---|---|---|---|
| Donor A . | Donor B . | Donor C . | Mean ± SD . | |
| Uninfected | 21.5 | 22.4 | 18.1 | 20.7 ± 1.8 |
| HIV | 36.0 (1290) | 58.2 (441) | 56.3 (2403) | 50.2 ± 10.0 |
| HIV + AZT | 15.4 (18) | 40.3 (29) | 17.6 (17) | 24.4 ± 11.3 |
| Δ°-HIV | 13.5 (61) | 20.2 (12) | 21.8 (19) | 18.5 ± 3.6 |
| . | MCP-1 (ng/mL) . | |||
|---|---|---|---|---|
| Donor A . | Donor B . | Donor C . | Mean ± SD . | |
| Uninfected | 21.5 | 22.4 | 18.1 | 20.7 ± 1.8 |
| HIV | 36.0 (1290) | 58.2 (441) | 56.3 (2403) | 50.2 ± 10.0 |
| HIV + AZT | 15.4 (18) | 40.3 (29) | 17.6 (17) | 24.4 ± 11.3 |
| Δ°-HIV | 13.5 (61) | 20.2 (12) | 21.8 (19) | 18.5 ± 3.6 |
Human MDM from three healthy donors were infected with HIV-1 BaL (MOI: 0.1) in the presence or absence of AZT (10 μmol/L), or they were exposed to heat-inactivated (Δ°)-HIV-1 BaL. MCP-1 was measured in the supernatants at peak RT activity (cpm/μL), which occurred at day 17 for donor A, and at day 20 for donors B and C, respectively.