LN-ras2 Reconstitution Summary
| . | Latency (d) . | Pathology . | Diagnosis . |
|---|---|---|---|
| Nr1 | 10 | Unrelated illness | |
| Nr2 | 11 | Reduced splenic hematopoiesis, hypoplastic BM. | Impaired reconstitution |
| Nr3 | 12 | Reduced splenic hematopoiesis, hypoplastic BM. | Impaired reconstitution |
| Nr4 | 14 | Reduced splenic hematopoiesis, hypoplastic BM, anemia, small thymus. | Impaired reconstitution |
| Nr5 | 14 | Reduced splenic hematopoiesis, hypoplastic BM, anemia, small thymus. | Impaired reconstitution |
| Nr6 | 26 | Reduced splenic hematopoiesis, hypoplastic BM, anemia. | Impaired reconstitution |
| Nr7 | 37 | Splenic nodes, erythroid hyperplasia in spleen, apoptosis in spleen, hypoplastic BM, anemia. | Impaired reconstitution, erythroid hyperplasia |
| Nr8 | 49 | Splenic nodes, erythroid hyperplasia in spleen, erythropoiesis in BM, aberrant erythrocytes, small thymus, apoptosis in the spleen. | Impaired reconstitution, erythroid hyperplasia |
| Nr9 | 50 | Splenic nodes, erythroid hyperplasia in spleen, mast cells in the spleen, hypoplastic BM, anemia, abberant erythrocytes, apoptosis in the spleen and thymus. | Impaired reconstitution, erythroid hyperplasia |
| Nr10 | 98 | ND | ND |
| Nr16 | 107 | Splenomegaly, small thymus, myelomonocytic hyperplasia, infiltrates within spleen, thymus, lung, liver, kidney, BM and PB, intestinal nodules, PB granulocytosis, apoptosis. | Myeloproliferative disorder |
| Nr17 | 141 | Splenomegaly, small thymus, mast cell hyperplasia, erythroid hyperplasia, mast cell infiltrates in spleen, liver, lung, BM and PB, BM hypoplasia, PB granulocytosis, anemia, aberrant erythrocytes, hematoma. | Mast cell disorder, erythroid hyperplasia |
| Nr18 | 144 | Splenomegaly, small thymus, myelomonocytic hyperplasia, infiltrates within spleen, thymus, lung, liver, kidney, BM and PB, lung tumor, PB granulocytosis, apoptosis. | Myeloproliferative disorder |
| Nr19 | 163 | ND | ND |
| Nr20 | 192 | Splenic nodes, small thymus, enlarged liver, mast cell hyperplasia, infiltrates within BM, liver and lung, PB blasts and monocytosis. | Monoblastic leukemia, mast cell disorder |
| Nr21 | 308 | Erythroid hyperplasia within spleen and BM. | Erythroid hyperplasia |
| Nr22 | 385 | Hind leg paralysis, splenomegaly, myelomonocytic hyperplasia, infiltrates within spleen, BM and lung, aberrant erythrocytes, apoptosis. | Myeloproliferative disorder |
| . | Latency (d) . | Pathology . | Diagnosis . |
|---|---|---|---|
| Nr1 | 10 | Unrelated illness | |
| Nr2 | 11 | Reduced splenic hematopoiesis, hypoplastic BM. | Impaired reconstitution |
| Nr3 | 12 | Reduced splenic hematopoiesis, hypoplastic BM. | Impaired reconstitution |
| Nr4 | 14 | Reduced splenic hematopoiesis, hypoplastic BM, anemia, small thymus. | Impaired reconstitution |
| Nr5 | 14 | Reduced splenic hematopoiesis, hypoplastic BM, anemia, small thymus. | Impaired reconstitution |
| Nr6 | 26 | Reduced splenic hematopoiesis, hypoplastic BM, anemia. | Impaired reconstitution |
| Nr7 | 37 | Splenic nodes, erythroid hyperplasia in spleen, apoptosis in spleen, hypoplastic BM, anemia. | Impaired reconstitution, erythroid hyperplasia |
| Nr8 | 49 | Splenic nodes, erythroid hyperplasia in spleen, erythropoiesis in BM, aberrant erythrocytes, small thymus, apoptosis in the spleen. | Impaired reconstitution, erythroid hyperplasia |
| Nr9 | 50 | Splenic nodes, erythroid hyperplasia in spleen, mast cells in the spleen, hypoplastic BM, anemia, abberant erythrocytes, apoptosis in the spleen and thymus. | Impaired reconstitution, erythroid hyperplasia |
| Nr10 | 98 | ND | ND |
| Nr16 | 107 | Splenomegaly, small thymus, myelomonocytic hyperplasia, infiltrates within spleen, thymus, lung, liver, kidney, BM and PB, intestinal nodules, PB granulocytosis, apoptosis. | Myeloproliferative disorder |
| Nr17 | 141 | Splenomegaly, small thymus, mast cell hyperplasia, erythroid hyperplasia, mast cell infiltrates in spleen, liver, lung, BM and PB, BM hypoplasia, PB granulocytosis, anemia, aberrant erythrocytes, hematoma. | Mast cell disorder, erythroid hyperplasia |
| Nr18 | 144 | Splenomegaly, small thymus, myelomonocytic hyperplasia, infiltrates within spleen, thymus, lung, liver, kidney, BM and PB, lung tumor, PB granulocytosis, apoptosis. | Myeloproliferative disorder |
| Nr19 | 163 | ND | ND |
| Nr20 | 192 | Splenic nodes, small thymus, enlarged liver, mast cell hyperplasia, infiltrates within BM, liver and lung, PB blasts and monocytosis. | Monoblastic leukemia, mast cell disorder |
| Nr21 | 308 | Erythroid hyperplasia within spleen and BM. | Erythroid hyperplasia |
| Nr22 | 385 | Hind leg paralysis, splenomegaly, myelomonocytic hyperplasia, infiltrates within spleen, BM and lung, aberrant erythrocytes, apoptosis. | Myeloproliferative disorder |
Abbreviation: ND, not determined.