Patient Characteristics and MTX Polyglutamylation Parameters in AML Subgroups
| FAB Type . | Age (mo) . | Sex M/F . | Number Initial/ Relapse . | FPGS Activity (pmol/h/106 cells) . | FPGH Activity (nmol/h/106 cells) . | MTX-Glu1-6 (pmol/109 cells) . | MTX-Glu4-6 (pmol/109 cells) . |
|---|---|---|---|---|---|---|---|
| M0 | 190 | 1/0 | 1/0 | 5.41 (1) | 0.56 (1) | — | — |
| M1 | 152 | 3/5 | 6/2 | 11.59 (3) | 0.92 (7) | 1418 (1) | 454 (1) |
| M2 | 103 | 5/4 | 9/0 | 1.56 (6) | 1.50 (8) | 1156 (5) | 270 (5) |
| M3 | 140 | 2/0 | 2/0 | 46.11 (1) | 1.67 (1) | 2103 (1) | 0 (1) |
| M4 | 156 | 5/5 | 7/3 | 7.46 (4) | 6.49 (10) | 486 (4) | 103 (3) |
| M5 | 37 | 0/2 | 2/0 | 6.90 (2) | 1.14 (2) | 1087 (2) | 216 (2) |
| M6 | 82 | 1/0 | 0/1 | 6.55 (1) | 1.85 (1) | ND | ND |
| M7 | 64 | 1/0 | 1/0 | 7.46 (1) | 0.30 (1) | ND | ND |
| ? | 161 | 0/1 | 1/0 | ND | 0.71 (1) | 1275 (1) | 791 (1) |
| FAB Type . | Age (mo) . | Sex M/F . | Number Initial/ Relapse . | FPGS Activity (pmol/h/106 cells) . | FPGH Activity (nmol/h/106 cells) . | MTX-Glu1-6 (pmol/109 cells) . | MTX-Glu4-6 (pmol/109 cells) . |
|---|---|---|---|---|---|---|---|
| M0 | 190 | 1/0 | 1/0 | 5.41 (1) | 0.56 (1) | — | — |
| M1 | 152 | 3/5 | 6/2 | 11.59 (3) | 0.92 (7) | 1418 (1) | 454 (1) |
| M2 | 103 | 5/4 | 9/0 | 1.56 (6) | 1.50 (8) | 1156 (5) | 270 (5) |
| M3 | 140 | 2/0 | 2/0 | 46.11 (1) | 1.67 (1) | 2103 (1) | 0 (1) |
| M4 | 156 | 5/5 | 7/3 | 7.46 (4) | 6.49 (10) | 486 (4) | 103 (3) |
| M5 | 37 | 0/2 | 2/0 | 6.90 (2) | 1.14 (2) | 1087 (2) | 216 (2) |
| M6 | 82 | 1/0 | 0/1 | 6.55 (1) | 1.85 (1) | ND | ND |
| M7 | 64 | 1/0 | 1/0 | 7.46 (1) | 0.30 (1) | ND | ND |
| ? | 161 | 0/1 | 1/0 | ND | 0.71 (1) | 1275 (1) | 791 (1) |
Numbers of patients are represented within parentheses.
Abbreviation: ND, not determined.