Table 2. Linkage Disequilibrium Between... | American Society of Hematology

Table 2.

Linkage Disequilibrium Between the −251G Allele and Other Polymorphic Loci Within the FECH Gene

	D^*	D%^†	χ² ^‡ (df = 1), P
IVS1 − 23T	0.19	91	36.0, <10⁻³
IVS2μsat:A9	0.10	44	9.7, <5 × 10⁻³
1520T	0.07	26	8.9, <2 × 10⁻²

	D^*	D%^†	χ² ^‡ (df = 1), P
IVS1 − 23T	0.19	91	36.0, <10⁻³
IVS2μsat:A9	0.10	44	9.7, <5 × 10⁻³
1520T	0.07	26	8.9, <2 × 10⁻²

Performed on 52 haplotypes observed in 26 unrelated Caucasian families.

Maximum likelihood of linkage disequilibrium. D = h − pq, where p and q are the frequencies of the rare alleles for the two loci analyzed and h is the frequency of the haplotype with the rare alleles at both loci.

†

Percentage of D maximum value at the given allele frequencies [Dm = p(1 − q)].

‡

The standardized value of D is Dx $\sqrt{N} /\sqrt{p (1 - p) q (1 - q)},$ whose square is asymptomatically distributed as a χ²random variable on 1 df. N is the total number of haplotypes used to determine the allelic frequencies of p and q.

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