Main Properties of Antiprothrombin and Anticardiolipin Antibodies
| . | Antiprothrombin Antibodies . | Anticardiolipin Antibodies . |
|---|---|---|
| Antigen | Prothrombin | β2-glycoprotein I, cardiolipin (“infectious” antibodies) |
| Epitopes | Fragment 1, prethrombin 1 | Domains 13-150 and 43-150 |
| Species-specificity | Mainly human | Human, bovine, rat, sheep |
| Affinity | Mainly low | Low |
| Lupus anticoagulant activity | Yes (a subgroup) | Yes (a subgroup) |
| Prevalence in the antiphospholipid syndrome | 50-90% (depending on antigen presentation) | 60-90% (depending on antigen presentation) |
| . | Antiprothrombin Antibodies . | Anticardiolipin Antibodies . |
|---|---|---|
| Antigen | Prothrombin | β2-glycoprotein I, cardiolipin (“infectious” antibodies) |
| Epitopes | Fragment 1, prethrombin 1 | Domains 13-150 and 43-150 |
| Species-specificity | Mainly human | Human, bovine, rat, sheep |
| Affinity | Mainly low | Low |
| Lupus anticoagulant activity | Yes (a subgroup) | Yes (a subgroup) |
| Prevalence in the antiphospholipid syndrome | 50-90% (depending on antigen presentation) | 60-90% (depending on antigen presentation) |
Data from McNeeley et al81 and Koike et al,82 respectively.