Main Laboratory Data of 25 Patients Classified by Their Lupus Anticoagulants
| Test . | Antiprothrombin Antibodies4-150 (n = 14) . | Anticardiolipin Antibodies (n = 11) . | P . |
|---|---|---|---|
| aPTT (ratio) | 1.40 ± 0.25 | 1.52 ± 0.35 | NS |
| KPTT (ratio) | 1.30 ± 0.24 | 1.38 ± 0.30 | NS |
| KCT (ratio) | 2.24 ± 0.41 | 1.50 ± 0.42 | .0002 |
| dRVVT (ratio) | 1.48 ± 0.28 | 2.20 ± 0.42 | .0001 |
| Anticardiolipin antibodies (U) | 61 ± 55 | 147 ± 43 | .0003 |
| Test . | Antiprothrombin Antibodies4-150 (n = 14) . | Anticardiolipin Antibodies (n = 11) . | P . |
|---|---|---|---|
| aPTT (ratio) | 1.40 ± 0.25 | 1.52 ± 0.35 | NS |
| KPTT (ratio) | 1.30 ± 0.24 | 1.38 ± 0.30 | NS |
| KCT (ratio) | 2.24 ± 0.41 | 1.50 ± 0.42 | .0002 |
| dRVVT (ratio) | 1.48 ± 0.28 | 2.20 ± 0.42 | .0001 |
| Anticardiolipin antibodies (U) | 61 ± 55 | 147 ± 43 | .0003 |
Data are expressed as mean ± SD.
Abbreviations: NS, not significant; aPTT, activated partial thromboplastin time; KPTT, activated partial thromboplastin time with kaolin as activator.
The antiprothrombin nature of the 14 lupus anticoagulants was defined according to the behavior of the IgG purified from plasma following adsorption with cardiolipin-containing liposomes in coagulation tests: the Igs retained phospholipid-dependent anticoagulant activity in human but not animal plasma, irrespective of the presence of β2-glycoprotein I (see ref 14).
Data from Galli et al.52