CD4+/CD8+ Cell Ratio and CD40L+ T Lymphocytes in the Reactive Background of HIV-HD as Assessed by IHC
| Case No. . | HD Subtype . | CD4+/CD8+ Cell Ratio . | CD40L† (%)*,† . |
|---|---|---|---|
| 1 | MC | 0.28 | 3.42 |
| 2 | MC | 0.12 | 0.26 |
| 3 | MC | 1.12 | |
| 4 | MC | 0.4 | 6.97 |
| 5 | MC | 1.47 | 7.3 |
| 6 | MC | 1.41 | 7.97 |
| 7 | MC | 0.26 | 2.8 |
| 8 | MC | 0.05 | |
| 9 | MC | 0.97 | 3.46 |
| 10 | MC | 0.28 | 1.16 |
| 11 | MC | 0.12 | |
| 12 | MC | 0.5 | |
| 13 | MC | 0.05 | |
| 14 | MC | 0.7 | |
| 15 | MC | 0.2 | |
| 16 | MC | 0.15 | |
| 17 | LD | 0.16 | |
| 18 | LD | 0.7 | 0.41 |
| 19 | LD | 0.19 | |
| 20 | LD | 1.41 | 1.06 |
| 21 | LD | 0.08 | |
| 22 | LD | 0.13 | |
| 23 | LD | 0.06 | |
| 24 | LD | 0.07 | |
| 25 | LD | 0.57 | 0.49 |
| 26 | NS | 0.13 | 4.8 |
| 27 | NS | 0.08 |
| Case No. . | HD Subtype . | CD4+/CD8+ Cell Ratio . | CD40L† (%)*,† . |
|---|---|---|---|
| 1 | MC | 0.28 | 3.42 |
| 2 | MC | 0.12 | 0.26 |
| 3 | MC | 1.12 | |
| 4 | MC | 0.4 | 6.97 |
| 5 | MC | 1.47 | 7.3 |
| 6 | MC | 1.41 | 7.97 |
| 7 | MC | 0.26 | 2.8 |
| 8 | MC | 0.05 | |
| 9 | MC | 0.97 | 3.46 |
| 10 | MC | 0.28 | 1.16 |
| 11 | MC | 0.12 | |
| 12 | MC | 0.5 | |
| 13 | MC | 0.05 | |
| 14 | MC | 0.7 | |
| 15 | MC | 0.2 | |
| 16 | MC | 0.15 | |
| 17 | LD | 0.16 | |
| 18 | LD | 0.7 | 0.41 |
| 19 | LD | 0.19 | |
| 20 | LD | 1.41 | 1.06 |
| 21 | LD | 0.08 | |
| 22 | LD | 0.13 | |
| 23 | LD | 0.06 | |
| 24 | LD | 0.07 | |
| 25 | LD | 0.57 | 0.49 |
| 26 | NS | 0.13 | 4.8 |
| 27 | NS | 0.08 |
Control cases included lymph node samples with CHD from 5 patients without HIV infection. The median tissue CD4+/CD8+ cell ratio was 4.13 (range, 2.18-9.77), and the percentage of lymphocytes expressing CD40L was 38.2%, 52.79%, 67.85%, 72.2%, and 75.12%, respectively.
The percentage of lymphocytes expressing CD40L was counted on the total of CD3+ T cells.
Anti-CD40L MoAb M90 was applied only to frozen sections (12 cases) because of its lack of reactivity in paraffin-embedded tissue sections.