Comparison of PML/RARA and PLZF/RARA Transgenic Phenotypes
| cDNA . | Regulatory Element . | Compartment of Expression . | Preleukemic State . | Leukemia Penetrance (%) . | Leukemia Latency (mo) . | Differentiation Block . | ATRA Response . |
|---|---|---|---|---|---|---|---|
| PML/RARA | hCG19 20 | Promyelocytes | Yes | 10-30 | 6-13 | Partial | Yes |
| PML/RARA | MRP822 | Pros → PMNs | Yes | 5 | 3-8 | Complete | Yes |
| PML/RARA | CD11b25 | Myelocyte → PMN | No | 0 | — | No | Not done |
| PLZF/RARA | hCG21 | Promyelocyte | Yes | 100 | 6-18 | Partial* | Minimal |
| cDNA . | Regulatory Element . | Compartment of Expression . | Preleukemic State . | Leukemia Penetrance (%) . | Leukemia Latency (mo) . | Differentiation Block . | ATRA Response . |
|---|---|---|---|---|---|---|---|
| PML/RARA | hCG19 20 | Promyelocytes | Yes | 10-30 | 6-13 | Partial | Yes |
| PML/RARA | MRP822 | Pros → PMNs | Yes | 5 | 3-8 | Complete | Yes |
| PML/RARA | CD11b25 | Myelocyte → PMN | No | 0 | — | No | Not done |
| PLZF/RARA | hCG21 | Promyelocyte | Yes | 100 | 6-18 | Partial* | Minimal |
Less pronounced accumulation of immature cells noted, compared with hCG-PML/RARA phenotype.