Table 1. Serum Iron, Liver Nonheme Iron,... | American Society of Hematology

Table 1.

Serum Iron, Liver Nonheme Iron, and Spleen Weight in Normal, Supplemented, and Overloaded Rats Treated for 0, 4, or 16 Days With 0, 10, 50, or 150 U rHuEpo Per Day

Category	Dose of rHuEpo (U/d)	Duration of Treatment (d)	SeFe (μd/dL)	Liver Nonheme Fe (μg)	Spleen Weight (mg)
Normal	—	Baseline	64 ± 10	326 ± 156	491 ± 67
	0	4	73 ± 16	385 ± 89	527 ± 75
		16	54 ± 15	341 ± 60	524 ± 48
	10	4	56 ± 8	312 ± 51	635 ± 105
		16	59 ± 30	318 ± 114	567 ± 72
	50	4	25 ± 12^*	292 ± 177	845 ± 167^†
		16	23 ± 11^*	131 ± 33^†	861 ± 148^*
	150	4	8 ± 4^‡	267 ± 106	1,187 ± 144^‡
		16	13 ± 4^‡	115 ± 9^†	1,105 ± 117^‡
Supplemented	—	Baseline	—	—	—
	0	16	80 ± 3	1,042 ± 92	485 ± 26
	50	16	64 ± 24	383 ± 266^†	1,453 ± 207^1-153
	150	16	24 ± 11^1-153	276 ± 88^‡	1,508 ± 207^1-153
Overloaded	—	Baseline	132 ± 26	5,376 ± 1,128	687 ± 83
	0	16	113 ± 19	4,203 ± 1,602	566 ± 90
	10	16	76 ± 11	4,601 ± 1,058	676 ± 23
	50	16	57 ± 10^*	2,333 ± 942^1-153	1,103 ± 118^*
	150	16	58 ± 7^*	2,282 ± 1,710^1-153	2,003 ± 571^†

Category	Dose of rHuEpo (U/d)	Duration of Treatment (d)	SeFe (μd/dL)	Liver Nonheme Fe (μg)	Spleen Weight (mg)
Normal	—	Baseline	64 ± 10	326 ± 156	491 ± 67
	0	4	73 ± 16	385 ± 89	527 ± 75
		16	54 ± 15	341 ± 60	524 ± 48
	10	4	56 ± 8	312 ± 51	635 ± 105
		16	59 ± 30	318 ± 114	567 ± 72
	50	4	25 ± 12^*	292 ± 177	845 ± 167^†
		16	23 ± 11^*	131 ± 33^†	861 ± 148^*
	150	4	8 ± 4^‡	267 ± 106	1,187 ± 144^‡
		16	13 ± 4^‡	115 ± 9^†	1,105 ± 117^‡
Supplemented	—	Baseline	—	—	—
	0	16	80 ± 3	1,042 ± 92	485 ± 26
	50	16	64 ± 24	383 ± 266^†	1,453 ± 207^1-153
	150	16	24 ± 11^1-153	276 ± 88^‡	1,508 ± 207^1-153
Overloaded	—	Baseline	132 ± 26	5,376 ± 1,128	687 ± 83
	0	16	113 ± 19	4,203 ± 1,602	566 ± 90
	10	16	76 ± 11	4,601 ± 1,058	676 ± 23
	50	16	57 ± 10^*	2,333 ± 942^1-153	1,103 ± 118^*
	150	16	58 ± 7^*	2,282 ± 1,710^1-153	2,003 ± 571^†

P values are given for comparisons with rats of the same category in baseline conditions.

P < .001.

P < .05.

P < .0001.

P < .01.

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