Previous Series Regarding the Prognostic Importance ofBcl-2 Rearrangement in FL
| Reference . | No. of Patients . | Histology . | Technique to Assess t(14;18) . | Prognostic Value of bcl-2 Rearrangement . | ||
|---|---|---|---|---|---|---|
| CR Rate . | DFS . | OS . | ||||
| Levine,18 1988 | 30 | FL | Cytogenetics | NS | NS | NS |
| Yunis,17 1989 | 20 | FL mixed/large cell | SB | MBR(+) > others | NA | MBR(+) > others |
| Pezzella,19 1992 | 70 | FL | SB/PCR | NA | NA | NS |
| Tilly,20 1994 | 66 | FL | Cytogenetics | NA | NA | NS |
| Johnson,16 1995 | 102 | FL (52 high-grade) | PCR | NA | NA | MBR(+) > others (low-grade) |
| Louie,21 1996 | 79 | FL | SB/cytogenetics | NA | NA | NS |
| This study, 1998 | 247 | Indolent FL | PCR | mcr(+)/MBR(+) > Others | mcr(+)/MBR(+) > Others | NS |
| Reference . | No. of Patients . | Histology . | Technique to Assess t(14;18) . | Prognostic Value of bcl-2 Rearrangement . | ||
|---|---|---|---|---|---|---|
| CR Rate . | DFS . | OS . | ||||
| Levine,18 1988 | 30 | FL | Cytogenetics | NS | NS | NS |
| Yunis,17 1989 | 20 | FL mixed/large cell | SB | MBR(+) > others | NA | MBR(+) > others |
| Pezzella,19 1992 | 70 | FL | SB/PCR | NA | NA | NS |
| Tilly,20 1994 | 66 | FL | Cytogenetics | NA | NA | NS |
| Johnson,16 1995 | 102 | FL (52 high-grade) | PCR | NA | NA | MBR(+) > others (low-grade) |
| Louie,21 1996 | 79 | FL | SB/cytogenetics | NA | NA | NS |
| This study, 1998 | 247 | Indolent FL | PCR | mcr(+)/MBR(+) > Others | mcr(+)/MBR(+) > Others | NS |
Abbreviations: DFS, disease-free survival; OS, overall survival; SB, Southern blot; NS, not significant; NA, not assessed; PCR, polymerase chain reaction.