Organ Involvement With Acute GVHD in the Two Study Arms According to Type of Donor
| . | HLA-Identical Sibling Donors . | Alternative Donors . | ||||
|---|---|---|---|---|---|---|
| Ciprofloxacin + Metronidazole . | Ciprofloxacin . | P Value4-150 . | Ciprofloxacin + Metronidazole . | Ciprofloxacin . | P Value4-150 . | |
| Skin4-151 | ||||||
| 0 | 11 (28) | 5 (13) | 7 (25) | 9 (35) | ||
| 1 | 5 (13) | 5 (13) | 3 (11) | 0 | ||
| 2 | 19 (48) | 12 (30) | <.007 | 10 (36) | 7 (27) | NS |
| 3 | 3 (8) | 11 (28) | 7 (25) | 7 (27) | ||
| 4 | 2 (5) | 7 (18) | 1 (4) | 3 (12) | ||
| Liver4-151 | ||||||
| 0 | 36 (90) | 27 (68) | 21 (75) | 16 (62) | ||
| 1 | 0 | 4 (10) | 1 (4) | 3 (12) | ||
| 2 | 0 | 1 (3) | <.06 | 2 (7) | 0 | NS |
| 3 | 1 (3) | 4 (10) | 0 | 4 (15) | ||
| 4 | 3 (8) | 4 (10) | 4 (14) | 3 (12) | ||
| Intestinal tract4-151 | ||||||
| 0 | 36 (90) | 27 (68) | 24 (86) | 19 (35) | ||
| 1 | 0 | 2 (5) | 0 | 0 | ||
| 2 | 0 | 3 (8) | <.04 | 0 | 0 | NS |
| 3 | 2 (5) | 1 (3) | 2 (7) | 1 (4) | ||
| 4 | 2 (5) | 7 (18) | 2 (7) | 6 (23) | ||
| No. of involved organs4-151 | ||||||
| 0 | 10 (25) | 5 (13) | 6 (21) | 9 (35) | ||
| 1 | 25 (63) | 19 (48) | <.004 | 16 (57) | 7 (27) | NS |
| 2 | 3 (8) | 6 (15) | 2 (7) | 3 (12) | ||
| 3 | 2 (5) | 10 (25) | 4 (14) | 7 (27) | ||
| Grades of acute GVHD4-151 | ||||||
| 0 | 10 (25) | 5 (5) | 6 (21) | 9 (35) | ||
| I | 23 (58) | 14 (35) | 12 (43) | 5 (19) | ||
| II | 2 (5) | 7 (18) | <.007 | 3 (11) | 5 (19) | NS |
| III | 1 (3) | 5 (13) | 2 (7) | 1 (4) | ||
| IV | 4 (10) | 9 (23) | 5 (18) | 6 (23) | ||
| . | HLA-Identical Sibling Donors . | Alternative Donors . | ||||
|---|---|---|---|---|---|---|
| Ciprofloxacin + Metronidazole . | Ciprofloxacin . | P Value4-150 . | Ciprofloxacin + Metronidazole . | Ciprofloxacin . | P Value4-150 . | |
| Skin4-151 | ||||||
| 0 | 11 (28) | 5 (13) | 7 (25) | 9 (35) | ||
| 1 | 5 (13) | 5 (13) | 3 (11) | 0 | ||
| 2 | 19 (48) | 12 (30) | <.007 | 10 (36) | 7 (27) | NS |
| 3 | 3 (8) | 11 (28) | 7 (25) | 7 (27) | ||
| 4 | 2 (5) | 7 (18) | 1 (4) | 3 (12) | ||
| Liver4-151 | ||||||
| 0 | 36 (90) | 27 (68) | 21 (75) | 16 (62) | ||
| 1 | 0 | 4 (10) | 1 (4) | 3 (12) | ||
| 2 | 0 | 1 (3) | <.06 | 2 (7) | 0 | NS |
| 3 | 1 (3) | 4 (10) | 0 | 4 (15) | ||
| 4 | 3 (8) | 4 (10) | 4 (14) | 3 (12) | ||
| Intestinal tract4-151 | ||||||
| 0 | 36 (90) | 27 (68) | 24 (86) | 19 (35) | ||
| 1 | 0 | 2 (5) | 0 | 0 | ||
| 2 | 0 | 3 (8) | <.04 | 0 | 0 | NS |
| 3 | 2 (5) | 1 (3) | 2 (7) | 1 (4) | ||
| 4 | 2 (5) | 7 (18) | 2 (7) | 6 (23) | ||
| No. of involved organs4-151 | ||||||
| 0 | 10 (25) | 5 (13) | 6 (21) | 9 (35) | ||
| 1 | 25 (63) | 19 (48) | <.004 | 16 (57) | 7 (27) | NS |
| 2 | 3 (8) | 6 (15) | 2 (7) | 3 (12) | ||
| 3 | 2 (5) | 10 (25) | 4 (14) | 7 (27) | ||
| Grades of acute GVHD4-151 | ||||||
| 0 | 10 (25) | 5 (5) | 6 (21) | 9 (35) | ||
| I | 23 (58) | 14 (35) | 12 (43) | 5 (19) | ||
| II | 2 (5) | 7 (18) | <.007 | 3 (11) | 5 (19) | NS |
| III | 1 (3) | 5 (13) | 2 (7) | 1 (4) | ||
| IV | 4 (10) | 9 (23) | 5 (18) | 6 (23) | ||