Univariable Analysis of Risk Factors for Chronic Liver Disease in Patients With Cirrhosis and Their Matched Controls
| . | Cases (n = 31) . | Controls (n = 31) . | P Value . |
|---|---|---|---|
| VOD | |||
| No. of patients (%) | 11 (35%) | 4 (13%) | .09 |
| Peak serum bilirubin (mg/dL) before day +20 (mean ± SEM) | 4.6 ± 1.3 | 2.3 ± 0.3 | NS |
| GVHD | |||
| Acute GVHD grade II-IV (%) | 9 (29%) | 12 (39%) | NS |
| Acute liver GVHD (%) | 7 (23%) | 7 (23%) | NS |
| Chronic liver GVHD (%) | 16 (52%) | 15 (48%) | NS |
| Immunosuppression | |||
| Median duration after day +100, months | 11.0 | 4.4 | NS |
| Patients treated for more than 1 yr | 15 (48%) | 13 (42%) | NS |
| Marrow iron stores at day 80 post-BMT3-150 (mean % ± SEM) | 45.4 ± 5.5 | 42.9 ± 5.3 | NS |
| HCV infection | |||
| HCV positive (%) | 25 (81%) | 14 (45%) | .01 |
| HCV genotype 1 (% of HCV positives) | 18 (86%) | 11 (79%) | NS |
| HCV genotype 2/3 (% of HCV positives) | 3 (14%) | 3 (21%) | NS |
| HBV infection | |||
| HBV positive (%) | 5 (16%)3-151 | 1 (3%)3-151 | NS |
| Other identifiable causes of liver disease | 23-152 | 0 |
| . | Cases (n = 31) . | Controls (n = 31) . | P Value . |
|---|---|---|---|
| VOD | |||
| No. of patients (%) | 11 (35%) | 4 (13%) | .09 |
| Peak serum bilirubin (mg/dL) before day +20 (mean ± SEM) | 4.6 ± 1.3 | 2.3 ± 0.3 | NS |
| GVHD | |||
| Acute GVHD grade II-IV (%) | 9 (29%) | 12 (39%) | NS |
| Acute liver GVHD (%) | 7 (23%) | 7 (23%) | NS |
| Chronic liver GVHD (%) | 16 (52%) | 15 (48%) | NS |
| Immunosuppression | |||
| Median duration after day +100, months | 11.0 | 4.4 | NS |
| Patients treated for more than 1 yr | 15 (48%) | 13 (42%) | NS |
| Marrow iron stores at day 80 post-BMT3-150 (mean % ± SEM) | 45.4 ± 5.5 | 42.9 ± 5.3 | NS |
| HCV infection | |||
| HCV positive (%) | 25 (81%) | 14 (45%) | .01 |
| HCV genotype 1 (% of HCV positives) | 18 (86%) | 11 (79%) | NS |
| HCV genotype 2/3 (% of HCV positives) | 3 (14%) | 3 (21%) | NS |
| HBV infection | |||
| HBV positive (%) | 5 (16%)3-151 | 1 (3%)3-151 | NS |
| Other identifiable causes of liver disease | 23-152 | 0 |
Except where indicated, figures refer to the number of patients.
Abbreviation: NS, not significant.
By morphometric method; expressed as total area of iron particles as a percentage of total area of hematopoietic cell nuclei.
All were also HCV positive.
Autoimmune hepatitis (UPN 6977) and amoxicillin-clavulanic acid-induced liver disease (UPN 7229) were each thought to contribute to severity of liver disease in 2 patients with chronic GVHD of the liver.