Table 4. Correlation Between CGH Losses... | American Society of Hematology

Table 4.

Correlation Between CGH Losses and Gene Deletions/Mutations by Southern Blot

Chromosomal Region	Gene Examined	Cases Studied	Gene Deletions^4-150
Chromosomal Region	Gene Examined	Cases Studied	CGH Loss	CGH Normal
9p	P16	20	3/3	2/17
13q	RB	11	0/3	0/8
17p	P53	22	6/6^4-151	0/16

Chromosomal Region	Gene Examined	Cases Studied	Gene Deletions^4-150
Chromosomal Region	Gene Examined	Cases Studied	CGH Loss	CGH Normal
9p	P16	20	3/3	2/17
13q	RB	11	0/3	0/8
17p	P53	22	6/6^4-151	0/16

Number of tumors with gene deletion/number of tumors examined by Southern blot. Not all cases examined by CGH could be analyzed molecularly.

Two cases had P53 homozygous deletions and 4 cases had hemyzygous deletions associated with gene mutation.