Laboratory Parameters and Serum HYA Levels in Myeloma Patients
| Parameters . | All Patients . | Serum Hyaluronan Level . | P* . | P† . | ||
|---|---|---|---|---|---|---|
| 0-9 μg/L . | 10-120 μg/L . | >120 μg/L . | ||||
| BM plasma cells (%) | 30.0 (0-100) | 48.5 (7-90) | 30.0 (0-100) | 30.0 (2-95) | .026 | .463 |
| Hemoglobin (g/L) | 106 (36-152) | 96 (71-144) | 108 (36-152) | 99 (68-138) | .002 | .004 |
| M-comp. conc. (g/L)‡ | 35 (0-121) | 56.5 (0-98) | 35.0 (0-121) | 26.5 (0-85) | .001 | .038 |
| IgG (g/L) (n = 224) | 64.0 (32-98) | 43.0 (1-121) | 38.0 (3-85) | .016 | .077 | |
| IgA (g/L) (n = 82) | 54.5 (16-68) | 34.0 (4-74) | 40.0 (9-55) | .009 | .499 | |
| β2-microglobulin (mg/L) | 4.8 (0.2-60.6) | 5.5 (2.3-39.3) | 4.4 (0.2-60.6) | 6.3 (1.7-48.0) | .503 | .005 |
| Albumin (g/L) | 34.0 (13-54) | 29.0 (23-45) | 35.0 (13-54) | 35.5 (16-46) | .025 | .710 |
| Parameters . | All Patients . | Serum Hyaluronan Level . | P* . | P† . | ||
|---|---|---|---|---|---|---|
| 0-9 μg/L . | 10-120 μg/L . | >120 μg/L . | ||||
| BM plasma cells (%) | 30.0 (0-100) | 48.5 (7-90) | 30.0 (0-100) | 30.0 (2-95) | .026 | .463 |
| Hemoglobin (g/L) | 106 (36-152) | 96 (71-144) | 108 (36-152) | 99 (68-138) | .002 | .004 |
| M-comp. conc. (g/L)‡ | 35 (0-121) | 56.5 (0-98) | 35.0 (0-121) | 26.5 (0-85) | .001 | .038 |
| IgG (g/L) (n = 224) | 64.0 (32-98) | 43.0 (1-121) | 38.0 (3-85) | .016 | .077 | |
| IgA (g/L) (n = 82) | 54.5 (16-68) | 34.0 (4-74) | 40.0 (9-55) | .009 | .499 | |
| β2-microglobulin (mg/L) | 4.8 (0.2-60.6) | 5.5 (2.3-39.3) | 4.4 (0.2-60.6) | 6.3 (1.7-48.0) | .503 | .005 |
| Albumin (g/L) | 34.0 (13-54) | 29.0 (23-45) | 35.0 (13-54) | 35.5 (16-46) | .025 | .710 |
Association between laboratory parameters and serum HYA levels in 386 patients with multiple myeloma. The HYA serum levels are grouped in abnormally low (0 to 9 μg/L; n = 20), intermediate (10 to 120 μg/L; n = 315), and high (>120 μg/L; n = 51) values.
Low versus intermediate HYA value group.
High versus intermediate HYA value group.
Seventy-two patients with light chain disease, 3 with IgD, and 1 nonsecretory patient are excluded.