Table 3. vWF Abnormal Fragments Found in... | American Society of Hematology

Table 3.

vWF Abnormal Fragments Found in Samples From Patients With Recurrent HUS/TTP With MoAbs Recognizing the N Terminus and the C Terminus of vWF Subunit

Patient	Disease Phase	MoAb Anti-N Terminus (RG7)	MoAb Anti-C Terminus (RG5)
Patient	Disease Phase	Abnormal Fragments	Abnormal Fragments
R1	Acute	No	Yes (140 kD^3-150)
	Remission	No	No
R7	Acute	No	No
	Remission	No	No
R12	Acute	Yes (176 kD^3-150)	Yes (140 kD^3-150)
	Remission	Yes (176 kD^3-150)	Yes (140 kD^3-150)
R13	Remission	Yes (189 kD^3-150)	No
R14	Acute	Yes (150 kD^3-150)	Yes (140 kD^3-150 and 150 kD^3-150)
	Remission	No	No
R15	Remission	No	No
R19	Remission	No	Yes (150 kD^3-150)
R20	Remission	No	No
R29	Acute	Yes (140 kD^3-151 and 176 kD^3-150)	Yes (150 kD^3-150 and 176 kD^3-152)

Patient	Disease Phase	MoAb Anti-N Terminus (RG7)	MoAb Anti-C Terminus (RG5)
Patient	Disease Phase	Abnormal Fragments	Abnormal Fragments
R1	Acute	No	Yes (140 kD^3-150)
	Remission	No	No
R7	Acute	No	No
	Remission	No	No
R12	Acute	Yes (176 kD^3-150)	Yes (140 kD^3-150)
	Remission	Yes (176 kD^3-150)	Yes (140 kD^3-150)
R13	Remission	Yes (189 kD^3-150)	No
R14	Acute	Yes (150 kD^3-150)	Yes (140 kD^3-150 and 150 kD^3-150)
	Remission	No	No
R15	Remission	No	No
R19	Remission	No	Yes (150 kD^3-150)
R20	Remission	No	No
R29	Acute	Yes (140 kD^3-151 and 176 kD^3-150)	Yes (150 kD^3-150 and 176 kD^3-152)

Presumed molecular weight extrapolated from the position of the band on gel.

The molecular weight of this band is slightly higher than normal N terminus 140 kD.

The molecular weight of this band is slightly lower than normal C terminus 176 kD.