Distribution of Genetic Polymorphisms in Survivors of Myocardial Infarction at a Young Age and Controls
| Polymorphisms/Mutations . | Cases (N = 200) . | Controls (N = 200) . | Odds Ratio (95% CI) . |
|---|---|---|---|
| 4G/5G PAI-1 gene | |||
| 5G5G | 69 (34.5) | 66 (33) | 1 (Reference) |
| 4G5G | 93 (46.5) | 102 (51) | 0.87 (0.55-1.39) |
| 4G4G | 38 (19) | 32 (16) | 1.14 (0.60-2.11) |
| Allele frequency | |||
| 5G | 231 (57.8) | 234 (58.5) | |
| 4G | 169 (42.2) | 166 (41.5) | 1.03 (0.97-1.38) |
| P1A1/P1A2 platelet glycoprotein IIIa gene | |||
| P1A1/P1A1 | 141 (70.5) | 163 (81.5) | 1 (Reference) |
| P1A1/P1A2 | 54 (27) | 33 (16.5) | 1.89 (1.13-3.18) |
| P1A2/P1A2 | 5 (2.5) | 4 (2) | 1.44 (0.31-6.6) |
| Allele frequency | |||
| P1A1 | 336 (84) | 359 (89.8) | |
| P1A2 | 64 (16) | 41 (10.2) | 1.67 (1.07-2.59) |
| C3550T platelet glycoprotein Ib gene | |||
| CC | 164 (82) | 162 (81) | 1 (Reference) |
| CT | 33 (16.5) | 37 (18.5) | 0.88 (0.51-1.52) |
| TT | 3 (1.5) | 1 (0.5) | 2.96 (0.25-85.9) |
| Allele frequency | |||
| C | 361 (90.2) | 362 (90.5) | |
| T | 39 (9.8) | 38 (9.5) | 1.13 (0.39-3.25) |
| G10976A factor VII gene | |||
| M1M1 | 143 (71.5) | 139 (69.5) | 1 (Reference) |
| M1M2 | 51 (25.5) | 56 (28) | 0.88 (0.55-1.41) |
| M2M2 | 6 (3) | 5 (2.5) | 1.16 (0.3-4.55) |
| Allele frequency | |||
| M1 | 337 (84.3) | 334 (83.5) | |
| M2 | 63 (15.7) | 66 (16.5) | 0.95 (0.64-1.4) |
| G1691A factor V gene | |||
| GG | 191 (95.5) | 192 (96) | 1 (Reference) |
| GA | 9 (4.5) | 8 (4) | 1.13 (0.38-3.31) |
| AA | 0 | 0 | |
| Allele frequency | |||
| G | 391 (97.8) | 392 (98) | |
| A | 9 (2.2) | 8 (2) | 1.13 (0.39-3.25) |
| C677T methylenetetrahydrofolate reductase gene | |||
| CC | 68 (34) | 60 (30) | 1 (Reference) |
| CT | 97 (48.5) | 102 (51) | 0.84 (0.52-1.34) |
| TT | 35 (17.5) | 38 (19) | 0.81 (0.44-1.51) |
| Allele frequency | |||
| C | 233 (58.2) | 227 (55.5) | |
| T | 167 (41.8) | 173 (44.5) | 0.89 (0.67-1.19) |
| G20210A prothrombin gene | |||
| GG | 189 (94.5) | 192 (96) | 1 (Reference) |
| GA | 11 (5.5) | 8 (4) | 1.40 (0.50-3.92) |
| AA | 0 | 0 | |
| Allele frequency | |||
| G | 389 (97.3) | 392 (98) | |
| A | 11 (2.7) | 8 (2) | 1.38 (0.50-3.83) |
| Polymorphisms/Mutations . | Cases (N = 200) . | Controls (N = 200) . | Odds Ratio (95% CI) . |
|---|---|---|---|
| 4G/5G PAI-1 gene | |||
| 5G5G | 69 (34.5) | 66 (33) | 1 (Reference) |
| 4G5G | 93 (46.5) | 102 (51) | 0.87 (0.55-1.39) |
| 4G4G | 38 (19) | 32 (16) | 1.14 (0.60-2.11) |
| Allele frequency | |||
| 5G | 231 (57.8) | 234 (58.5) | |
| 4G | 169 (42.2) | 166 (41.5) | 1.03 (0.97-1.38) |
| P1A1/P1A2 platelet glycoprotein IIIa gene | |||
| P1A1/P1A1 | 141 (70.5) | 163 (81.5) | 1 (Reference) |
| P1A1/P1A2 | 54 (27) | 33 (16.5) | 1.89 (1.13-3.18) |
| P1A2/P1A2 | 5 (2.5) | 4 (2) | 1.44 (0.31-6.6) |
| Allele frequency | |||
| P1A1 | 336 (84) | 359 (89.8) | |
| P1A2 | 64 (16) | 41 (10.2) | 1.67 (1.07-2.59) |
| C3550T platelet glycoprotein Ib gene | |||
| CC | 164 (82) | 162 (81) | 1 (Reference) |
| CT | 33 (16.5) | 37 (18.5) | 0.88 (0.51-1.52) |
| TT | 3 (1.5) | 1 (0.5) | 2.96 (0.25-85.9) |
| Allele frequency | |||
| C | 361 (90.2) | 362 (90.5) | |
| T | 39 (9.8) | 38 (9.5) | 1.13 (0.39-3.25) |
| G10976A factor VII gene | |||
| M1M1 | 143 (71.5) | 139 (69.5) | 1 (Reference) |
| M1M2 | 51 (25.5) | 56 (28) | 0.88 (0.55-1.41) |
| M2M2 | 6 (3) | 5 (2.5) | 1.16 (0.3-4.55) |
| Allele frequency | |||
| M1 | 337 (84.3) | 334 (83.5) | |
| M2 | 63 (15.7) | 66 (16.5) | 0.95 (0.64-1.4) |
| G1691A factor V gene | |||
| GG | 191 (95.5) | 192 (96) | 1 (Reference) |
| GA | 9 (4.5) | 8 (4) | 1.13 (0.38-3.31) |
| AA | 0 | 0 | |
| Allele frequency | |||
| G | 391 (97.8) | 392 (98) | |
| A | 9 (2.2) | 8 (2) | 1.13 (0.39-3.25) |
| C677T methylenetetrahydrofolate reductase gene | |||
| CC | 68 (34) | 60 (30) | 1 (Reference) |
| CT | 97 (48.5) | 102 (51) | 0.84 (0.52-1.34) |
| TT | 35 (17.5) | 38 (19) | 0.81 (0.44-1.51) |
| Allele frequency | |||
| C | 233 (58.2) | 227 (55.5) | |
| T | 167 (41.8) | 173 (44.5) | 0.89 (0.67-1.19) |
| G20210A prothrombin gene | |||
| GG | 189 (94.5) | 192 (96) | 1 (Reference) |
| GA | 11 (5.5) | 8 (4) | 1.40 (0.50-3.92) |
| AA | 0 | 0 | |
| Allele frequency | |||
| G | 389 (97.3) | 392 (98) | |
| A | 11 (2.7) | 8 (2) | 1.38 (0.50-3.83) |
The values denote numbers of case patients or controls followed by percentage of the total for that group in parentheses.