FISH With 5q and 11p Probes on t(5;11) Cases
| Probe Name . | Gene/DNA Marker . | Location . | FISH Signal* . | ||
|---|---|---|---|---|---|
| Patient No. 1 . | Patient No. 2 . | Patient No. 3 . | |||
| 5q31 Oncor† | 5q31 | ND | ND | − | |
| y335D9‡ | ADRB2 | 5q31.3 | ND | ND | + |
| cSPARC1-153 | SPARC | 5q32-q33 | ND | ND | + |
| y757H21-155 | GRIA1 | 5q33 | ND | ND | + |
| y822E101-155 | IL12B | 5q33 | ND | ND | + |
| y802F51-155 | D5S671 | 5q34 | − | − | + |
| y889G51-155 | DRD1 | 5q35.1 | − | − | ND |
| c13, c15-21-154 | NPM1 | 5q35 | − | − | + |
| cFLT41-154 | FLT4 | 5q35.3 | +/der(11) | +/der(11) | +/der(11) |
| yRP12a3# | RDPX1 | 11p15.5 | +/der(11) | +/der(11) | +/der(11) |
| cos91G21-160 | HRAS1-HRC | 11p15.5 | +/der(5) | +/der(5) | +/der(5) |
| Probe Name . | Gene/DNA Marker . | Location . | FISH Signal* . | ||
|---|---|---|---|---|---|
| Patient No. 1 . | Patient No. 2 . | Patient No. 3 . | |||
| 5q31 Oncor† | 5q31 | ND | ND | − | |
| y335D9‡ | ADRB2 | 5q31.3 | ND | ND | + |
| cSPARC1-153 | SPARC | 5q32-q33 | ND | ND | + |
| y757H21-155 | GRIA1 | 5q33 | ND | ND | + |
| y822E101-155 | IL12B | 5q33 | ND | ND | + |
| y802F51-155 | D5S671 | 5q34 | − | − | + |
| y889G51-155 | DRD1 | 5q35.1 | − | − | ND |
| c13, c15-21-154 | NPM1 | 5q35 | − | − | + |
| cFLT41-154 | FLT4 | 5q35.3 | +/der(11) | +/der(11) | +/der(11) |
| yRP12a3# | RDPX1 | 11p15.5 | +/der(11) | +/der(11) | +/der(11) |
| cos91G21-160 | HRAS1-HRC | 11p15.5 | +/der(5) | +/der(5) | +/der(5) |
Refers to signal on the der(5), unless otherwise stated.
Abbreviations: c, cosmid; y, YAC; ND, not done; ADRB2,adrenergic receptor β2; SPARC, secreted protein, acidic and cysteine rich; GRIA1, glutamate receptor; IL12B, one of the two subunits of interleukin-12; DRD1, dopamine receptor D1;NPM1, nucleophosmin; FLT4, fms-related tyrosine kinase 4; RDPX1, radixin pseudogene; HRAS1, Harveyras-1; HRC, HRAS1-related gene complex.
Oncor Laboratories (Birtley, UK).
Li et al.37
S.W. Morris, unpublished results (the SPARC EST insert was obtained from the American Type Culture Collection).
Kostrzewa et al.35
Overlapping clones immediately centromeric to NPM1 locus were cohybridized.38
Russell et al.20