Analysis of Tumor-Derived VH Genes
| Patient . | VH Family . | Germline Gene . | % Homology . | R/S Mutation . | JH . | Tumor-Derived Clones/Clones Sequenced . | |
|---|---|---|---|---|---|---|---|
| FR . | CDR . | ||||||
| CLE | VH3 | V3-74 | 92.9 | 6/7 | 8/0 | JH6b | 6/8 |
| DEZ | VH3 | V3-7 | 96.9 | 4/3 | 1/1 | JH4b | 7/10 |
| JON | VH3 | V3-7 | 93.2 | 5/5 | 7/3 | JH3b | 7/8 |
| MOR | VH3 | V3-7 | 95.9 | 5/4 | 3/0 | JH4b | 11/12 |
| BEC | VH3 | V3-7 | 95.9 | 4/1 | 5/3 | JH4b | 8/9 |
| BAR | VH3 | V3-73 | 94.0 | 5/2 | 8/3 | JH4b | 8/9 |
| Patient . | VH Family . | Germline Gene . | % Homology . | R/S Mutation . | JH . | Tumor-Derived Clones/Clones Sequenced . | |
|---|---|---|---|---|---|---|---|
| FR . | CDR . | ||||||
| CLE | VH3 | V3-74 | 92.9 | 6/7 | 8/0 | JH6b | 6/8 |
| DEZ | VH3 | V3-7 | 96.9 | 4/3 | 1/1 | JH4b | 7/10 |
| JON | VH3 | V3-7 | 93.2 | 5/5 | 7/3 | JH3b | 7/8 |
| MOR | VH3 | V3-7 | 95.9 | 5/4 | 3/0 | JH4b | 11/12 |
| BEC | VH3 | V3-7 | 95.9 | 4/1 | 5/3 | JH4b | 8/9 |
| BAR | VH3 | V3-73 | 94.0 | 5/2 | 8/3 | JH4b | 8/9 |
Abbreviations: R/S, replacement/silent; FR, framework region; CDR, complementary-determining region.