Table 3. In Vitro MDR Variables... | American Society of Hematology

Table 3.

In Vitro MDR Variables Influencing Achievement of CR (using the threshold of positivity)

Variables^3-150 (thresholds of positivity)^3-151	Response to Treatment		P Value^3-152
Variables^3-150 (thresholds of positivity)^3-151	No.	% CR	P Value^3-152
Pgp expression (1.3)
Positive	31	51	.02
Negative	29	79
MRP1 expression (1.4)
Positive	20	45	.02
Negative	40	75
Modulatory effect of CsA on calcein-AM uptake (1.39)
Positive	14	42	.03
Negative	26	76
Modulatory effect of probenecid on calcein-AM uptake (1.28)
Positive	11	36	.02
Negative	29	75
Modulatory effect of CsA + probenecid on calcein-AM uptake (1.41)
Positive	18	33	.0001
Negative	22	90

Variables^3-150 (thresholds of positivity)^3-151	Response to Treatment		P Value^3-152
Variables^3-150 (thresholds of positivity)^3-151	No.	% CR	P Value^3-152
Pgp expression (1.3)
Positive	31	51	.02
Negative	29	79
MRP1 expression (1.4)
Positive	20	45	.02
Negative	40	75
Modulatory effect of CsA on calcein-AM uptake (1.39)
Positive	14	42	.03
Negative	26	76
Modulatory effect of probenecid on calcein-AM uptake (1.28)
Positive	11	36	.02
Negative	29	75
Modulatory effect of CsA + probenecid on calcein-AM uptake (1.41)
Positive	18	33	.0001
Negative	22	90

None of the other in vitro resistance parameters, Mvp/LRP expression, LC50 DNR, LC50 etoposide, or LC50 Ara-C, had prognostic significance.

The thresholds of positivity were defined in Figs 2, 3, and 5.

Using χ² test.