Significant Prognostic Variables for RFS and OS
| Variables4-150 . | RFS (P value) . | OS (Pvalue) . |
|---|---|---|
| In Vitro Resistance Parameters | ||
| Effect of both probenecid and CsA on calcein-AM uptake | .01 | .02 |
| LC50 Ara-C | .02 | .001 |
| Clinical and Biological Parameters | ||
| Age | .03 | .01 |
| Cytogenetics | .04 | .01 |
| WBC | .03 | .04 |
| Variables4-150 . | RFS (P value) . | OS (Pvalue) . |
|---|---|---|
| In Vitro Resistance Parameters | ||
| Effect of both probenecid and CsA on calcein-AM uptake | .01 | .02 |
| LC50 Ara-C | .02 | .001 |
| Clinical and Biological Parameters | ||
| Age | .03 | .01 |
| Cytogenetics | .04 | .01 |
| WBC | .03 | .04 |
Only variables with P values ≤.05 on log regression were recorded in the table. The other variables with a P value >.05 were MDR1, MRP1, and Mvp/LRP expression (by RT-PCR and flow cytometry); Pgp and MRP1 activity (the effect of either CsA or probenecid on calcein-AM uptake, respectively); LC50 DNR and LC50 etoposide; and CD34 expression.