Haplotype Analysis of Eight Patients With CDA Type I (cases 1-8) and Two Normal Unaffected Relatives (cases 9 and 10)
| Cases . | D15S779 . | D15S780 . | D15S515 . | D15S778 . | ||||
|---|---|---|---|---|---|---|---|---|
| Allele pair . | Allele pair . | Allele pair . | Allele pair . | |||||
| 1 | 6 | 6 | 3 | 1 | 1 | 1 | 5 | 4 |
| 2 | 1 | 1 | 2 | 1 | 1 | 1 | 4 | 3 |
| 3 | 6 | 5 | 3 | 2 | 1 | 1 | 4 | 2 |
| 4 | 6 | 5 | 2 | 1 | 1 | 1 | 4 | 1 |
| 5 | 2 | 1 | 2 | 1 | 1 | 1 | 3 | 3 |
| 6 | 6 | 3 | 1 | 1 | 1 | 1 | 4 | 3 |
| 7* | 4 | 4 | 1 | 1 | 1 | 1 | 2 | 2 |
| 8* | 4 | 4 | 1 | 1 | 1 | 1 | 2 | 2 |
| 9 | 6 | 4 | 1 | 1 | 1 | 1 | 4 | 2 |
| 10 | 6 | 6 | 3 | 1 | 1 | 1 | 3 | 1 |
| Cases . | D15S779 . | D15S780 . | D15S515 . | D15S778 . | ||||
|---|---|---|---|---|---|---|---|---|
| Allele pair . | Allele pair . | Allele pair . | Allele pair . | |||||
| 1 | 6 | 6 | 3 | 1 | 1 | 1 | 5 | 4 |
| 2 | 1 | 1 | 2 | 1 | 1 | 1 | 4 | 3 |
| 3 | 6 | 5 | 3 | 2 | 1 | 1 | 4 | 2 |
| 4 | 6 | 5 | 2 | 1 | 1 | 1 | 4 | 1 |
| 5 | 2 | 1 | 2 | 1 | 1 | 1 | 3 | 3 |
| 6 | 6 | 3 | 1 | 1 | 1 | 1 | 4 | 3 |
| 7* | 4 | 4 | 1 | 1 | 1 | 1 | 2 | 2 |
| 8* | 4 | 4 | 1 | 1 | 1 | 1 | 2 | 2 |
| 9 | 6 | 4 | 1 | 1 | 1 | 1 | 4 | 2 |
| 10 | 6 | 6 | 3 | 1 | 1 | 1 | 3 | 1 |
The order of the microsatellite markers, which span a 0.5-cM region on chromosome 15q, is D15S779 (telomeric), D15S780, D15S515, and D15S778 (centromeric).
Related Lebanese CDA type I patients (cases 7 and 8). Case 7 is the nephew of case 8. The unaffected sister of case 8 (ie, mother of case 7) and unaffected father of case 4 are designated as cases 9 and 10, respectively.