Correlation of Plasma Levels of nm23-H1 With Clinical and Prognostic Characteristics in Intermediate- and High-Grade Non-Hodgkin’s Lymphoma
| Characteristic . | No. of Patients . | Mediannm23-H1 Level (ng/mL) . | P Value* . |
|---|---|---|---|
| Age at diagnosis (yr) | |||
| <60 | 59 | 29.1 | .5435 |
| ≥60 | 90 | 30.5 | |
| Gender | |||
| Male | 84 | 29.0 | 1.0000 |
| Female | 65 | 30.4 | |
| WHO performance status | |||
| 0, 1 | 131 | 28.4 | .0069 |
| 2 ∼ 4 | 18 | 58.8 | |
| Serum LDH level | |||
| Normal | 39 | 23.2 | .0926 |
| >Normal | 110 | 33.4 | |
| Ann Arbor stage | |||
| I, II | 61 | 21.3 | .0176 |
| III, IV | 88 | 35.2 | |
| Extranodal sites | |||
| ≤1 | 141 | 29.6 | .4310 |
| >1 | 8 | 52.3 | |
| IPI | |||
| Low/low-intermediate | 100 | 28.7 | .2429 |
| High-intermediate/high | 49 | 32.5 | |
| Immunophenotype | |||
| T | 37 | 39.1 | .0145 |
| B | 112 | 28.1 | |
| Soluble IL-2 receptor level (U/mL) | |||
| <1,000 | 83 | 24.4 | .0018 |
| ≥1,000 | 66 | 41.1 | |
| Soluble CD44 level (ng/mL) | |||
| <1,000 | 95 | 28.2 | .4932 |
| ≥1,000 | 17 | 35.0 | |
| Therapeutic response | |||
| CR | 126 | 37.4 | .0001 |
| PR + nonresponse | 23 | 93.6 |
| Characteristic . | No. of Patients . | Mediannm23-H1 Level (ng/mL) . | P Value* . |
|---|---|---|---|
| Age at diagnosis (yr) | |||
| <60 | 59 | 29.1 | .5435 |
| ≥60 | 90 | 30.5 | |
| Gender | |||
| Male | 84 | 29.0 | 1.0000 |
| Female | 65 | 30.4 | |
| WHO performance status | |||
| 0, 1 | 131 | 28.4 | .0069 |
| 2 ∼ 4 | 18 | 58.8 | |
| Serum LDH level | |||
| Normal | 39 | 23.2 | .0926 |
| >Normal | 110 | 33.4 | |
| Ann Arbor stage | |||
| I, II | 61 | 21.3 | .0176 |
| III, IV | 88 | 35.2 | |
| Extranodal sites | |||
| ≤1 | 141 | 29.6 | .4310 |
| >1 | 8 | 52.3 | |
| IPI | |||
| Low/low-intermediate | 100 | 28.7 | .2429 |
| High-intermediate/high | 49 | 32.5 | |
| Immunophenotype | |||
| T | 37 | 39.1 | .0145 |
| B | 112 | 28.1 | |
| Soluble IL-2 receptor level (U/mL) | |||
| <1,000 | 83 | 24.4 | .0018 |
| ≥1,000 | 66 | 41.1 | |
| Soluble CD44 level (ng/mL) | |||
| <1,000 | 95 | 28.2 | .4932 |
| ≥1,000 | 17 | 35.0 | |
| Therapeutic response | |||
| CR | 126 | 37.4 | .0001 |
| PR + nonresponse | 23 | 93.6 |
Abbreviation: LDH, lactate dehydrogenase.
Mann-Whitney test.