Table 2.

Prognostic Factors in a Univariate Analysis

Characteristic No. of Patients3-yr Survival (%) P Value3-yr PFS (%) P Value
Wilcoxon Test Log-Rank Test Wilcoxon Test Log-Rank Test
Age at diagnosis (yr)  
 <60  59  80.2  .0096 .0055  74.9  .0343  .0314  
 ≥60  90  54.5   57.7  
Gender  
 Male  84  64.2  .9083 .8921  59.6  .7351  .4104  
 Female  65  67.9   71.8  
WHO performance status  
 0, 1  131 71.8  .0001  .0001  69.8  .0001  .0001 
 2 ∼ 4  18  0.0    22.0  
Serum LDH level  
 Normal  39  85.7  .0160  .0101  80.7 .0447  .0301  
 >Normal  110  58.2    58.4 
Ann Arbor stage  
 I, II  61  69.4  .1167 .2022  65.6  .1923  .3998  
 III, IV  88  62.6   64.2  
Extranodal sites  
 ≤1  141  66.5 .1283  .1995  65.7  .2874  .2175  
 >1  8 51.4    41.7  
IPI  
 Low/low-intermediate 100  73.8  .0021  .0016  69.7  .0245  .0273 
 High-intermediate/high  49  45.6    53.0 
Immunophenotype  
 T  37  41.1  .0065  .0023 49.7  .0232  .0214  
 B  112  72.7    69.3 
Soluble IL-2 receptor level (U/mL)  
 <1,000  83 76.0  .0002  .0006  73.9  .0080  .0063  
 ≥1,000 66  50.6    50.0  
Soluble CD44 level (ng/mL) 
 <1,000  95  65.8  .0321  .0554  64.2  .1016 .1449  
 ≥1,000  17  51.5    52.9 
nm23-H1 level (ng/mL)  
 <80  121  79.5 .0001  .0001  73.0  .0001  .0001  
 ≥80  28 6.7    20.6 
Characteristic No. of Patients3-yr Survival (%) P Value3-yr PFS (%) P Value
Wilcoxon Test Log-Rank Test Wilcoxon Test Log-Rank Test
Age at diagnosis (yr)  
 <60  59  80.2  .0096 .0055  74.9  .0343  .0314  
 ≥60  90  54.5   57.7  
Gender  
 Male  84  64.2  .9083 .8921  59.6  .7351  .4104  
 Female  65  67.9   71.8  
WHO performance status  
 0, 1  131 71.8  .0001  .0001  69.8  .0001  .0001 
 2 ∼ 4  18  0.0    22.0  
Serum LDH level  
 Normal  39  85.7  .0160  .0101  80.7 .0447  .0301  
 >Normal  110  58.2    58.4 
Ann Arbor stage  
 I, II  61  69.4  .1167 .2022  65.6  .1923  .3998  
 III, IV  88  62.6   64.2  
Extranodal sites  
 ≤1  141  66.5 .1283  .1995  65.7  .2874  .2175  
 >1  8 51.4    41.7  
IPI  
 Low/low-intermediate 100  73.8  .0021  .0016  69.7  .0245  .0273 
 High-intermediate/high  49  45.6    53.0 
Immunophenotype  
 T  37  41.1  .0065  .0023 49.7  .0232  .0214  
 B  112  72.7    69.3 
Soluble IL-2 receptor level (U/mL)  
 <1,000  83 76.0  .0002  .0006  73.9  .0080  .0063  
 ≥1,000 66  50.6    50.0  
Soluble CD44 level (ng/mL) 
 <1,000  95  65.8  .0321  .0554  64.2  .1016 .1449  
 ≥1,000  17  51.5    52.9 
nm23-H1 level (ng/mL)  
 <80  121  79.5 .0001  .0001  73.0  .0001  .0001  
 ≥80  28 6.7    20.6 
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