Clinical and Laboratory Features of Patients With Non–A-E FH
| Patient No. . | Age (yr) . | Race . | Sex . | Duration . | AST/ALT . | Protime . | Bilirubin . | HGV RNA . | Therapeutic Transfusion . | Other Risk Factors . | OLT . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 49 | W | M | 2 | 200/475 | 51.0 | 451 | + | − | − | + | Died |
| 2 | 57 | A | F | 14 | 2,200/2,500 | 14.9 | 238 | − | − | − | − | Died |
| 3 | 18 | W | F | 10 | 1,800/2,100 | 17.0 | 386 | − | − | − | + | Died |
| 4 | 35 | W | F | 20 | 825/628 | 16.3 | 408 | − | − | − | + | Alive |
| 5 | 55 | W | M | 45 | 1,336/550 | 21.1 | 350 | − | − | − | − | Died |
| 6 | 33 | W | F | >120 | 1,165/600 | 33.4 | 400 | − | − | − | + | Alive |
| 7 | 56 | W | F | 68 | 2,152/2,242 | 22.8 | 84 | − | − | − | + | Died |
| 8 | 65 | W | M | >120 | 695/1,030 | 18.2 | 561 | − | − | − | − | Died |
| 9 | 55 | W | M | 68 | 275/372 | 23.6 | 401 | − | − | − | − | Died |
| 10 | 16 | W | F | 25 | 3,660/9,980 | 23.7 | 51 | − | − | − | − | Alive |
| 11 | 26 | W | M | 20 | 548/913 | >50 | 679 | − | − | − | − | Died |
| 12 | 50 | W | F | 15 | 2,800/3,700 | 24.0 | 306 | + | − | − | + | Died |
| 13 | 25 | W | F | 7 | 2,974/3,752 | 26.5 | 645 | − | − | − | − | Died |
| 14 | 58 | W | M | 21 | 2,493/3,133 | 15.9 | 238 | − | − | − | − | Alive |
| 15 | 38 | W | F | 18 | 954/1,012 | 31.0 | 197 | − | FFP | − | − | Died |
| 16 | 26 | W | M | 37 | 4,881/3,471 | 22.0 | 85 | − | − | − | − | Died |
| 17 | 14 | W | F | 4 | 1,900/2,580 | 17.3 | 425 | − | − | − | − | Died |
| 18 | 28 | W | F | 5 | 939/747 | 61.9 | 527 | + | Plasmapheresis | − | − | Died |
| 19 | 58 | W | F | 42 | 143/170 | 16.2 | 394 | − | FFP | − | + | Alive |
| 20 | 32 | B | M | 3 | 4,620/7,460 | 29 | 459 | + | − | − | − | Died |
| 21 | 33 | W | F | 18 | 1,664/643 | 26.6 | 85 | + | Plasmapheresis | − | − | Alive |
| 22 | 19 | W | F | 7 | 1,810/2,112 | 31.5 | 78 | − | Plasmapheresis | − | − | Died |
| 23 | 28 | B | F | 4 | 10,749/6,996 | 45 | 213 | + | Plasmapheresis | − | − | Died |
| 24 | 69 | W | F | 10 | 909/960 | 40.7 | 391 | − | FFP | − | − | Died |
| 25 | 31 | B | F | 8 | 784/548 | 42.1 | 612 | + | Plasmapheresis | − | − | Died |
| 26 | 16 | B | F | 21 | 207/142 | 33 | 352 | + | Plasmapheresis | − | + | Alive |
| 27 | 18 | W | M | 35 | 386/570 | 23 | 765 | + | FFP | − | − | Alive |
| 28 | 26 | B | F | 3 | 2,580/5,460 | 40 | 62 | + | FFP | − | + | Alive |
| 29 | 39 | W | F | 70 | 450/280 | 23 | 330 | − | − | − | + | Alive |
| 30 | 49 | W | F | 50 | 267/234 | 22.6 | 323 | − | FFP | − | + | Died |
| 31 | 18 | W | F | 54 | 809/818 | 15.0 | 204 | + | Plasmapheresis | − | + | Alive |
| 32 | 47 | W | F | 7 | 568/436 | 35.5 | 374 | + | Plasmapheresis | − | + | Alive |
| 33 | 30 | B | F | 14 | 1,028/984 | 52.4 | 391 | + | Plasmapheresis | − | + | Died |
| 34 | 15 | W | F | 22 | 324/365 | 23.4 | 476 | − | Plasmapheresis | − | − | Alive |
| 35 | 33 | W | M | 7 | 6,274/4,721 | 28.4 | 54 | − | Plasmapheresis | − | − | Alive |
| 36 | 20 | B | F | 2 | 255/1,413 | 38.4 | 340 | + | − | − | − | Died |
| Total | 35.7 ± 16 | W: 89% | F: 73% | 27.7 ± 30 | 1,823 ± 2,114 | 29.7 ± 12 | 342.6 ± 186 | (+): 38.8% | 17/36 (47.2%) | 0% | 14/36 (38.8%) | Died: 62.2% |
| 2,058 ± 2,356 |
| Patient No. . | Age (yr) . | Race . | Sex . | Duration . | AST/ALT . | Protime . | Bilirubin . | HGV RNA . | Therapeutic Transfusion . | Other Risk Factors . | OLT . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 49 | W | M | 2 | 200/475 | 51.0 | 451 | + | − | − | + | Died |
| 2 | 57 | A | F | 14 | 2,200/2,500 | 14.9 | 238 | − | − | − | − | Died |
| 3 | 18 | W | F | 10 | 1,800/2,100 | 17.0 | 386 | − | − | − | + | Died |
| 4 | 35 | W | F | 20 | 825/628 | 16.3 | 408 | − | − | − | + | Alive |
| 5 | 55 | W | M | 45 | 1,336/550 | 21.1 | 350 | − | − | − | − | Died |
| 6 | 33 | W | F | >120 | 1,165/600 | 33.4 | 400 | − | − | − | + | Alive |
| 7 | 56 | W | F | 68 | 2,152/2,242 | 22.8 | 84 | − | − | − | + | Died |
| 8 | 65 | W | M | >120 | 695/1,030 | 18.2 | 561 | − | − | − | − | Died |
| 9 | 55 | W | M | 68 | 275/372 | 23.6 | 401 | − | − | − | − | Died |
| 10 | 16 | W | F | 25 | 3,660/9,980 | 23.7 | 51 | − | − | − | − | Alive |
| 11 | 26 | W | M | 20 | 548/913 | >50 | 679 | − | − | − | − | Died |
| 12 | 50 | W | F | 15 | 2,800/3,700 | 24.0 | 306 | + | − | − | + | Died |
| 13 | 25 | W | F | 7 | 2,974/3,752 | 26.5 | 645 | − | − | − | − | Died |
| 14 | 58 | W | M | 21 | 2,493/3,133 | 15.9 | 238 | − | − | − | − | Alive |
| 15 | 38 | W | F | 18 | 954/1,012 | 31.0 | 197 | − | FFP | − | − | Died |
| 16 | 26 | W | M | 37 | 4,881/3,471 | 22.0 | 85 | − | − | − | − | Died |
| 17 | 14 | W | F | 4 | 1,900/2,580 | 17.3 | 425 | − | − | − | − | Died |
| 18 | 28 | W | F | 5 | 939/747 | 61.9 | 527 | + | Plasmapheresis | − | − | Died |
| 19 | 58 | W | F | 42 | 143/170 | 16.2 | 394 | − | FFP | − | + | Alive |
| 20 | 32 | B | M | 3 | 4,620/7,460 | 29 | 459 | + | − | − | − | Died |
| 21 | 33 | W | F | 18 | 1,664/643 | 26.6 | 85 | + | Plasmapheresis | − | − | Alive |
| 22 | 19 | W | F | 7 | 1,810/2,112 | 31.5 | 78 | − | Plasmapheresis | − | − | Died |
| 23 | 28 | B | F | 4 | 10,749/6,996 | 45 | 213 | + | Plasmapheresis | − | − | Died |
| 24 | 69 | W | F | 10 | 909/960 | 40.7 | 391 | − | FFP | − | − | Died |
| 25 | 31 | B | F | 8 | 784/548 | 42.1 | 612 | + | Plasmapheresis | − | − | Died |
| 26 | 16 | B | F | 21 | 207/142 | 33 | 352 | + | Plasmapheresis | − | + | Alive |
| 27 | 18 | W | M | 35 | 386/570 | 23 | 765 | + | FFP | − | − | Alive |
| 28 | 26 | B | F | 3 | 2,580/5,460 | 40 | 62 | + | FFP | − | + | Alive |
| 29 | 39 | W | F | 70 | 450/280 | 23 | 330 | − | − | − | + | Alive |
| 30 | 49 | W | F | 50 | 267/234 | 22.6 | 323 | − | FFP | − | + | Died |
| 31 | 18 | W | F | 54 | 809/818 | 15.0 | 204 | + | Plasmapheresis | − | + | Alive |
| 32 | 47 | W | F | 7 | 568/436 | 35.5 | 374 | + | Plasmapheresis | − | + | Alive |
| 33 | 30 | B | F | 14 | 1,028/984 | 52.4 | 391 | + | Plasmapheresis | − | + | Died |
| 34 | 15 | W | F | 22 | 324/365 | 23.4 | 476 | − | Plasmapheresis | − | − | Alive |
| 35 | 33 | W | M | 7 | 6,274/4,721 | 28.4 | 54 | − | Plasmapheresis | − | − | Alive |
| 36 | 20 | B | F | 2 | 255/1,413 | 38.4 | 340 | + | − | − | − | Died |
| Total | 35.7 ± 16 | W: 89% | F: 73% | 27.7 ± 30 | 1,823 ± 2,114 | 29.7 ± 12 | 342.6 ± 186 | (+): 38.8% | 17/36 (47.2%) | 0% | 14/36 (38.8%) | Died: 62.2% |
| 2,058 ± 2,356 |
Total values are the means ± SD.
Abbreviations: W, caucasian; B, Afro-American; A, Asian; Duration, days from onset of jaundice to encephalopathy; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Protime, prothrombin time in seconds; Bilirubin, in micromoles per liter (normal, 5 to 17 μmol/L); HGV RNA, qualitative HGV RNA in serum; FFP, fresh frozen plasma; plasmapheresis, exchange plasmapheresis (removal of plasma and replacement with FFP); OLT, orthotopic liver transplantation.