Table 1. Change in Second-Order Rate... | American Society of Hematology

Table 1.

Change in Second-Order Rate Constants of fXa Inhibition

Active Form	α-Antithrombin		β-Antithrombin
Active Form	− Heparin (mmol/L⁻¹s⁻¹)	+ Heparin (mmol/L⁻¹s⁻¹)	− Heparin (mmol/L⁻¹s⁻¹)	+ Heparin (mmol/L⁻¹s⁻¹)	L:β, 10:1 (mmol/L⁻¹s⁻¹)	10:1, + Heparin (mmol/L⁻¹s⁻¹)
(as) Monomer	3.75 ± 0.01	2,170 ± 190	7.16 ± 0.15	2,410 ± 180	7.16 ± 0.15	2,410 ± 180
(in) Dimer	3.34 ± 0.08	1,720 ± 160	5.65 ± 0.05	1,630 ± 130	3.79 ± 0.15	843 ± 33
Activity loss	11%	21%	21%	33%	47%	65%

Active Form	α-Antithrombin		β-Antithrombin
Active Form	− Heparin (mmol/L⁻¹s⁻¹)	+ Heparin (mmol/L⁻¹s⁻¹)	− Heparin (mmol/L⁻¹s⁻¹)	+ Heparin (mmol/L⁻¹s⁻¹)	L:β, 10:1 (mmol/L⁻¹s⁻¹)	10:1, + Heparin (mmol/L⁻¹s⁻¹)
(as) Monomer	3.75 ± 0.01	2,170 ± 190	7.16 ± 0.15	2,410 ± 180	7.16 ± 0.15	2,410 ± 180
(in) Dimer	3.34 ± 0.08	1,720 ± 160	5.65 ± 0.05	1,630 ± 130	3.79 ± 0.15	843 ± 33
Activity loss	11%	21%	21%	33%	47%	65%