Role of Maintenance According to the Induction Regimen Administered
| Outcomes . | Maintenance Randomized Group . | ||||
|---|---|---|---|---|---|
| Induction Group . | ATRA Alone . | No Maintenance . | ATRA and Chemotherapy . | Chemotherapy Alone . | P Value . |
| ATRA → CT | n = 18 | n = 23 | n = 19 | n = 21 | |
| Relapse at 2 yr | 12% | 22% | 12% | 7% | .06 |
| EFS at 2 yr | 88% | 71% | 88% | 88% | .03 |
| Survival at 2 yr | 100% | 79% | 92% | 95% | .16 |
| ATRA + CT | n = 20 | n = 17 | n = 20 | n = 16 | |
| Relapse at 2 yr | 7% | 29% | 0 | 8% | .056 |
| EFS at 2 yr | 87% | 71% | 100% | 92% | .096 |
| Survival at 2 yr | 86% | 92% | 100% | 100% | .23 |
| High WBC group | n = 30 | n = 28 | n = 29 | n = 30 | |
| Relapse at 2 yr | 35% | 47% | 8% | 26% | .002 |
| EFS at 2 yr | 75% | 53% | 92% | 74% | .005 |
| Survival at 2 yr | 88% | 67% | 95% | 92% | .018 |
| Elderly group | n = 4 | n = 6 | n = 6 | n = 4 | |
| Relapse at 2 yr | 0 | 17% | 17% | 0 | .76 |
| EFS at 2 yr | 100% | 83% | 67% | 100% | .52 |
| Survival at 2 yr | 100% | 100% | 67% | 100% | .13 |
| Outcomes . | Maintenance Randomized Group . | ||||
|---|---|---|---|---|---|
| Induction Group . | ATRA Alone . | No Maintenance . | ATRA and Chemotherapy . | Chemotherapy Alone . | P Value . |
| ATRA → CT | n = 18 | n = 23 | n = 19 | n = 21 | |
| Relapse at 2 yr | 12% | 22% | 12% | 7% | .06 |
| EFS at 2 yr | 88% | 71% | 88% | 88% | .03 |
| Survival at 2 yr | 100% | 79% | 92% | 95% | .16 |
| ATRA + CT | n = 20 | n = 17 | n = 20 | n = 16 | |
| Relapse at 2 yr | 7% | 29% | 0 | 8% | .056 |
| EFS at 2 yr | 87% | 71% | 100% | 92% | .096 |
| Survival at 2 yr | 86% | 92% | 100% | 100% | .23 |
| High WBC group | n = 30 | n = 28 | n = 29 | n = 30 | |
| Relapse at 2 yr | 35% | 47% | 8% | 26% | .002 |
| EFS at 2 yr | 75% | 53% | 92% | 74% | .005 |
| Survival at 2 yr | 88% | 67% | 95% | 92% | .018 |
| Elderly group | n = 4 | n = 6 | n = 6 | n = 4 | |
| Relapse at 2 yr | 0 | 17% | 17% | 0 | .76 |
| EFS at 2 yr | 100% | 83% | 67% | 100% | .52 |
| Survival at 2 yr | 100% | 100% | 67% | 100% | .13 |
ATRA → CT, ATRA followed by chemotherapy; ATRA + CT, chemotherapy started on day 3 of ATRA treatment; high WBC group, patients with presenting WBC count above 5,000/μL; elderly group: patients older than 65.
Abbreviation: EFS, event-free survival.