Frequency of Chromosomal Abnormalities in Children (Compared With Adults) With AML
| Chromosome Abnormality . | Children . | Adults . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 19881 No. (%) . | 19892 No. (%) . | 19953 No. (%) . | 19964 No. (%) . | 199854-150 No. (%) . | Total1-5 4-151 No. (%) . | Present No. (%) . | Total4-151 No. (%) . | 19985‡ No. (%) . | 1998234-153 No. (%) . | Total5 23 No. (%) . | |
| Total | 130 | 121 | 115 | 220 | 340 | 926 | 478 | 1,404 | 1,272 | 609 | 1,881 |
| Normal | 41 (31) | 25 (21) | 17 (15) | 61 (28) | 91 (27) | 235 (25) | 109 (23) | 344 (24) | 589 (46) | 245 (40) | 834 (44) |
| t(8;21)(q22;q22) | 17 (13) | 14 (12) | 9 (8) | 36 (16) | 41 (12) | 117 (13) | 56 (12) | 173 (12) | 81 (6) | 40 (7) | 121 (6) |
| inv(16)(p13q22)/t(16;16) | 4 (3) | 15 (12) | 9 (8) | 19 (9) | 16 (6) | 63 (7) | 28 (6) | 91 (6) | 41 (3) | 49 (8) | 90 (5) |
| t(15;17)(q22;q12-21) | 10 (8) | 9 (7) | 12 (10) | 9 (4) | 31 (9) | 71 (8) | 55 (11) | 126 (9) | 167 (13) | 27 (4) | 194 (10) |
| t(9;11)(p22;q23) | 0 | 9 (7) | 10 (9) | 16 (7) | NA | 35 (6) | 35 (7) | 70 (7) | NA | NA | NA |
| t(11q23;V)/inv/del(11q23) | 12 (9) | 7 (6) | 11 (10) | 21 (9) | 26 (8) | 77 (8) | 53 (11) | 130 (9) | 34 (3)4-155 | 42 (7)4-155 | 76 (4) |
| t(6;9)(p23;q24) | 0 | 0 | 1 (<1) | NA | NA | 1 (<1) | 6 (1) | 7 (<1) | NA | 11 (2) | 11 (2) |
| t(1;22)(p13;q13) | 0 | 0 | 4 (3) | NA | NA | 4 (1) | 4 (<1) | 8 (<1) | NA | 0 | NA |
| −7/del(7q) | 6 (5) | 6 (5) | 6 (5) | NA | 19 (6) | 37 (5) | 21 (4) | 58 (5) | 74 (6) | 52 (8) | 126 (7) |
| −5/del(5q) | 2 (1) | 1 (<1) | 0 | NA | 6 (2) | 9 (1) | 6 (1) | 15 (1) | 48 (4) | 36 (6) | 84 (4) |
| Hyperdiploid | 14 (11) | 17 (14) | 24 (21) | NA | NA | 55 (15) | 77 (16) | 132 (16) | NA | NA | NA |
| 47-50 | 13 (10) | 14 (12) | 20 (17)4-154 | NA | NA | 47 (13) | 69 (14) | 116 (14) | NA | NA | NA |
| >50 | 1 (<1) | 3 (2) | 4 (3) | NA | NA | 8 (2) | 8 (2) | 16 (2) | NA | NA | NA |
| +8 Overall | 7 (5) | 7 (6) | 12 (10) | NA | 46 (14) | 72 (10) | 40 (8) | 112 (9) | 102 (8) | 28 (5) | 130 (7) |
| +21 Overall | 5 (4) | 5 (4) | 4 (3) | NA | 20 (5) | 34 (5) | 26 (5) | 60 (5) | 25 (2) | NA | 25 (2) |
| Chromosome Abnormality . | Children . | Adults . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 19881 No. (%) . | 19892 No. (%) . | 19953 No. (%) . | 19964 No. (%) . | 199854-150 No. (%) . | Total1-5 4-151 No. (%) . | Present No. (%) . | Total4-151 No. (%) . | 19985‡ No. (%) . | 1998234-153 No. (%) . | Total5 23 No. (%) . | |
| Total | 130 | 121 | 115 | 220 | 340 | 926 | 478 | 1,404 | 1,272 | 609 | 1,881 |
| Normal | 41 (31) | 25 (21) | 17 (15) | 61 (28) | 91 (27) | 235 (25) | 109 (23) | 344 (24) | 589 (46) | 245 (40) | 834 (44) |
| t(8;21)(q22;q22) | 17 (13) | 14 (12) | 9 (8) | 36 (16) | 41 (12) | 117 (13) | 56 (12) | 173 (12) | 81 (6) | 40 (7) | 121 (6) |
| inv(16)(p13q22)/t(16;16) | 4 (3) | 15 (12) | 9 (8) | 19 (9) | 16 (6) | 63 (7) | 28 (6) | 91 (6) | 41 (3) | 49 (8) | 90 (5) |
| t(15;17)(q22;q12-21) | 10 (8) | 9 (7) | 12 (10) | 9 (4) | 31 (9) | 71 (8) | 55 (11) | 126 (9) | 167 (13) | 27 (4) | 194 (10) |
| t(9;11)(p22;q23) | 0 | 9 (7) | 10 (9) | 16 (7) | NA | 35 (6) | 35 (7) | 70 (7) | NA | NA | NA |
| t(11q23;V)/inv/del(11q23) | 12 (9) | 7 (6) | 11 (10) | 21 (9) | 26 (8) | 77 (8) | 53 (11) | 130 (9) | 34 (3)4-155 | 42 (7)4-155 | 76 (4) |
| t(6;9)(p23;q24) | 0 | 0 | 1 (<1) | NA | NA | 1 (<1) | 6 (1) | 7 (<1) | NA | 11 (2) | 11 (2) |
| t(1;22)(p13;q13) | 0 | 0 | 4 (3) | NA | NA | 4 (1) | 4 (<1) | 8 (<1) | NA | 0 | NA |
| −7/del(7q) | 6 (5) | 6 (5) | 6 (5) | NA | 19 (6) | 37 (5) | 21 (4) | 58 (5) | 74 (6) | 52 (8) | 126 (7) |
| −5/del(5q) | 2 (1) | 1 (<1) | 0 | NA | 6 (2) | 9 (1) | 6 (1) | 15 (1) | 48 (4) | 36 (6) | 84 (4) |
| Hyperdiploid | 14 (11) | 17 (14) | 24 (21) | NA | NA | 55 (15) | 77 (16) | 132 (16) | NA | NA | NA |
| 47-50 | 13 (10) | 14 (12) | 20 (17)4-154 | NA | NA | 47 (13) | 69 (14) | 116 (14) | NA | NA | NA |
| >50 | 1 (<1) | 3 (2) | 4 (3) | NA | NA | 8 (2) | 8 (2) | 16 (2) | NA | NA | NA |
| +8 Overall | 7 (5) | 7 (6) | 12 (10) | NA | 46 (14) | 72 (10) | 40 (8) | 112 (9) | 102 (8) | 28 (5) | 130 (7) |
| +21 Overall | 5 (4) | 5 (4) | 4 (3) | NA | 20 (5) | 34 (5) | 26 (5) | 60 (5) | 25 (2) | NA | 25 (2) |
Abbreviations: NA, not available; V, variable chromosome.
Age group in years 0-14.
Percentages for specific abnormalities exclude unavailable cases.
Age group in years 15-55, included secondary leukemias due to chemotherapy or prior MDS.
SWOG/ECOG intergroup trial in AML, patients aged 16-55 years.
The t(9;11) cases were included in the 11q23 subgroup.
Hyperdiploid cases classified as 47-48 and 49.