Individual clones obtained from 3 REP⁺/MSP⁺ (cases 33, 42, and 44) and 2 REP⁺/MSP⁻ lymphomas (cases 36 and 47) were sequenced. The clones from REP⁺/MSP⁺ cases display complete or almost complete methylation. The clones from REP⁺/MSP⁻ cases are either sparsely methylated or completely unmethylated.

Abbreviations: +, methylated CpG dinucleotides; −, unmethylated CpG dinucleotides.

Fourty-two CpG dinucleotides (numbered 1 to 42) contained in a 483-bp fragment of p16 exon 1. The numbers in gray boxes correspond to the 3 CpG sites assessed by digestion with KspI (K) andHpaII (H). The 11 CpG sites covered by the primers used for MSP-analysis are underlined by asterisks (forward primer) or small circles (reverse primers).