IgV Gene Analysis in Normal and Malignant B Cells
| Probable Normal Precursor . | Malignancy . | Mutational Status . | Mutation Ongoing? . |
|---|---|---|---|
| Bm1, Bm2 (naive B-lymphocytes) | Some B-CLL, mantle cell lymphoma | Unmutated | No |
| Bm3, Bm4 (germinal center cells; centroblast, centrocyte) | Burkitt’s lymphoma, follicular cell lymphoma, diffuse large-cell lymphoma | Mutated | Yes |
| Bm5 (memory cell) | Some B-CLL | Mutated | No |
| Plasma cell | Multiple myeloma | Mutated | No |
| Probable Normal Precursor . | Malignancy . | Mutational Status . | Mutation Ongoing? . |
|---|---|---|---|
| Bm1, Bm2 (naive B-lymphocytes) | Some B-CLL, mantle cell lymphoma | Unmutated | No |
| Bm3, Bm4 (germinal center cells; centroblast, centrocyte) | Burkitt’s lymphoma, follicular cell lymphoma, diffuse large-cell lymphoma | Mutated | Yes |
| Bm5 (memory cell) | Some B-CLL | Mutated | No |
| Plasma cell | Multiple myeloma | Mutated | No |