Table 1. NK Cell Activity and Lymphocyte... | American Society of Hematology

Table 1.

NK Cell Activity and Lymphocyte Subpopulation of 5 FHL Patients at Onset

Patient No.	Age/Sex	Affected Siblings	NK Activity (%)^*	CD3 (%)	CD19 (%)	CD56 (%)	CD3/DR (%)^†	CD4 (%)	CD8 (%)	Outcome
1	1 mo/M	+	NT	82.5	6.8	7.2	$\underset{̲}{46.3}$	63.8	11.4	Died of PD after BMT (13 mo)
2	18 mo/F	+	19.0 (⁠ $\underset{̲}{1.0}$ ⁠)^‡	77.9	10.3	12.8	$\underset{̲}{63.0}$	$\underset{̲}{15.9}$	$\underset{̲}{65.3}$	Died of PD (3.5 mo)
3	2 mo/M	+	$\underset{̲}{1.0}$	85.6	4.7	8.8	$\underset{̲}{19.8}$	57.7	28.1	Alive after CBSCT (+23 mo)
4	17 mo/F	+	$\underset{̲}{1.0}$	59.4	29.2	9.1	$\underset{̲}{14.5}$	27.3	25.3	Alive after CBSCT (+35 mo)
5	1 mo/M	+	$\underset{̲}{9.0}$	67.1	15.8	14.6	0.5	47.1	22.9	Died of PD (3 mo)

Patient No.	Age/Sex	Affected Siblings	NK Activity (%)^*	CD3 (%)	CD19 (%)	CD56 (%)	CD3/DR (%)^†	CD4 (%)	CD8 (%)	Outcome
1	1 mo/M	+	NT	82.5	6.8	7.2	$\underset{̲}{46.3}$	63.8	11.4	Died of PD after BMT (13 mo)
2	18 mo/F	+	19.0 (⁠ $\underset{̲}{1.0}$ ⁠)^‡	77.9	10.3	12.8	$\underset{̲}{63.0}$	$\underset{̲}{15.9}$	$\underset{̲}{65.3}$	Died of PD (3.5 mo)
3	2 mo/M	+	$\underset{̲}{1.0}$	85.6	4.7	8.8	$\underset{̲}{19.8}$	57.7	28.1	Alive after CBSCT (+23 mo)
4	17 mo/F	+	$\underset{̲}{1.0}$	59.4	29.2	9.1	$\underset{̲}{14.5}$	27.3	25.3	Alive after CBSCT (+35 mo)
5	1 mo/M	+	$\underset{̲}{9.0}$	67.1	15.8	14.6	0.5	47.1	22.9	Died of PD (3 mo)

Abnormal values are underlined.

Abbreviations: NT, not tested; PD, progressive disease.

Normal range is 18% to 46%.19

Normal range of CD3⁺/DR⁺ cells is 6.4 ± 4.8.19

In patient no. 2, 19% of NK activity decreased to 1% after 1 month.