Table 2. Effect of Transferrin (Tf)... | American Society of Hematology

Table 2.

Effect of Transferrin (Tf) Injections on Intestinal Iron Absorption

Tf Dose (mg)	n	Δt	Mucosal Retention	Mucosal Transfer	Total Uptake	Mucosal Transfer (%)
Tf Dose (mg)	n	Δt	(pmol/mg/10 min)			Mucosal Transfer (%)
Nil	6	—	28.4 ± 10.7	63.2 ± 14.4	91.5 ± 12.9	69.0 ± 11.1
1	6	4-5 h	39.3 ± 14.5	67.2 ± 12.0	107 ± 23	63.9 ± 7.9
1	4	24 h	29.9 ± 12.9	57.3 ± 21.2	87.2 ± 31.9	66.1 ± 7.3
2 × 1 over 24 h	5	6 h^*	47.2 ± 17.8	62.7 ± 12.1	110 ± 21.1	57.7 ± 10.6
2.2	3	3 d	33.6 ± 19.0	80.8 ± 33.2	114 ± 52	71.7 ± 4.0
4.4	4	1 d	30.0 ± 6.1	51.4 ± 13.0	81.4 ± 16.0	62.7 ± 6.3
4.4	4	3 d	23.2 ± 18.6	53.6 ± 38.9	76.8 ± 57.2	71.1 ± 8.4
4.4	4	7 d	33.0 ± 10.0	42.9 ± 27.7	75.9 ± 33.3	52.7 ± 14.1
2 × 4.4 over 1 wk	4	3 d^*	23.5 ± 6.6	28.7 ± 14.2^‡	52.2 ± 18.2^†	53.4 ± 10.6

Tf Dose (mg)	n	Δt	Mucosal Retention	Mucosal Transfer	Total Uptake	Mucosal Transfer (%)
Tf Dose (mg)	n	Δt	(pmol/mg/10 min)			Mucosal Transfer (%)
Nil	6	—	28.4 ± 10.7	63.2 ± 14.4	91.5 ± 12.9	69.0 ± 11.1
1	6	4-5 h	39.3 ± 14.5	67.2 ± 12.0	107 ± 23	63.9 ± 7.9
1	4	24 h	29.9 ± 12.9	57.3 ± 21.2	87.2 ± 31.9	66.1 ± 7.3
2 × 1 over 24 h	5	6 h^*	47.2 ± 17.8	62.7 ± 12.1	110 ± 21.1	57.7 ± 10.6
2.2	3	3 d	33.6 ± 19.0	80.8 ± 33.2	114 ± 52	71.7 ± 4.0
4.4	4	1 d	30.0 ± 6.1	51.4 ± 13.0	81.4 ± 16.0	62.7 ± 6.3
4.4	4	3 d	23.2 ± 18.6	53.6 ± 38.9	76.8 ± 57.2	71.1 ± 8.4
4.4	4	7 d	33.0 ± 10.0	42.9 ± 27.7	75.9 ± 33.3	52.7 ± 14.1
2 × 4.4 over 1 wk	4	3 d^*	23.5 ± 6.6	28.7 ± 14.2^‡	52.2 ± 18.2^†	53.4 ± 10.6

Data: mean ± SD for (n) experiments.

Abbreviations: Δt, sampling time after the single or second injection.*

P < .02.

P < .006 as compared with untreated homozygous mice.