Effect of Daily Transferrin Injections on Circulating Transferrin, Hemoglobin, and Liver Iron in Homozygous Hypotransferrinemic Mice
| Group . | n . | Serum Transferrin (mg/mL) . | Hemoglobin (g/100 mL) . | Liver Iron (nmol/mg) . | |
|---|---|---|---|---|---|
| Mouse . | Human . | ||||
| Controls | 10 | 2.1 ± 0.6* | ND | 17.4 ± 1.1 | 1.9 ± 0.8 |
| trfhpx | 6 | <0.053-151 | ND | 5.8 ± 0.93-152 | 27.4 ± 3.13-152 |
| Daily mTf injections | 5 | 0.88 ± 0.253-153 | ND | 15.4 ± 3.13-155 | 6.5 ± 2.43-155 |
| Daily mTf–left for 1 wk | 6 | 0.13 ± 0.093-154 | ND | 14.6 ± 2.4 | 4.9 ± 3.0 |
| Daily hTf injections | 5 | <0.053-151 | 1.04 ± 0.6 | 14.9 ± 1.73-155 | 9.1 ± 4.53-155 |
| Daily hTf–left for 1 wk | 5 | <0.053-151 | <0.05 | 13.2 ± 1.1 | 11.2 ± 3.4 |
| Daily hAlb injections | 3 | <0.05 | ND | 4.9 ± 1.4 | 22.9 ± 7.3 |
| Group . | n . | Serum Transferrin (mg/mL) . | Hemoglobin (g/100 mL) . | Liver Iron (nmol/mg) . | |
|---|---|---|---|---|---|
| Mouse . | Human . | ||||
| Controls | 10 | 2.1 ± 0.6* | ND | 17.4 ± 1.1 | 1.9 ± 0.8 |
| trfhpx | 6 | <0.053-151 | ND | 5.8 ± 0.93-152 | 27.4 ± 3.13-152 |
| Daily mTf injections | 5 | 0.88 ± 0.253-153 | ND | 15.4 ± 3.13-155 | 6.5 ± 2.43-155 |
| Daily mTf–left for 1 wk | 6 | 0.13 ± 0.093-154 | ND | 14.6 ± 2.4 | 4.9 ± 3.0 |
| Daily hTf injections | 5 | <0.053-151 | 1.04 ± 0.6 | 14.9 ± 1.73-155 | 9.1 ± 4.53-155 |
| Daily hTf–left for 1 wk | 5 | <0.053-151 | <0.05 | 13.2 ± 1.1 | 11.2 ± 3.4 |
| Daily hAlb injections | 3 | <0.05 | ND | 4.9 ± 1.4 | 22.9 ± 7.3 |
Data: mean ± SD for (n) determinations except for “*” where n = 6. Mouse (mTf) or human (hTf) transferrin, as appropriate, was assayed in the serum of noninjected or injected hypotransferrinemic mice.
Abbreviations: ND, not determined; hAlb, human albumin.
P < .05.
P < .001 as compared with the control group.
P < .03.
P < .002 as compared with untreated trfhpxmice.
P < .002 as compared with values in the appropriate 3-week–treated group.