Table 4. Iron Absorption in... | American Society of Hematology

Table 4.

Iron Absorption in Hypotransferrinemic Mice Injected Daily for 3 Weeks With Either Mouse or Human Transferrin

Group	n	Mucosal Retention	Mucosal Transfer	Total Uptake	Mucosal Transfer (%)
Group	n	(pmol/mg/10 min)			Mucosal Transfer (%)
trf^hpx	6	28.4 ± 10.7	63.2 ± 14.4	91.5 ± 12.9	69.0 ± 11.1
Daily mTf injections	5	23.1 ± 4.4	37.9 ± 13.5^4-150	61.0 ± 17.5^4-150,^4-151	61.2 ± 4.9
Daily mTf–left for 1 wk	6	35.8 ± 13.7	72.5 ± 28.8^4-153	108 ± 30^4-153	65.6 ± 11.9
Daily hTf injections	5	22.7 ± 5.5	11.1 ± 5.4^‡	33.9 ± 9.7^‡	32.0 ± 8.5^‡
Daily hTf–left for 1 wk	5	43.9 ± 15.6^4-153	59.9 ± 32.2^4-153	104 ± 42^4-153	54.0 ± 17.2^4-153
Daily hAlb injections	3	61.4 ± 15.6^4-151	81.5 ± 14.0	143 ± 28^4-151	57.3 ± 4.3

Group	n	Mucosal Retention	Mucosal Transfer	Total Uptake	Mucosal Transfer (%)
Group	n	(pmol/mg/10 min)			Mucosal Transfer (%)
trf^hpx	6	28.4 ± 10.7	63.2 ± 14.4	91.5 ± 12.9	69.0 ± 11.1
Daily mTf injections	5	23.1 ± 4.4	37.9 ± 13.5^4-150	61.0 ± 17.5^4-150,^4-151	61.2 ± 4.9
Daily mTf–left for 1 wk	6	35.8 ± 13.7	72.5 ± 28.8^4-153	108 ± 30^4-153	65.6 ± 11.9
Daily hTf injections	5	22.7 ± 5.5	11.1 ± 5.4^‡	33.9 ± 9.7^‡	32.0 ± 8.5^‡
Daily hTf–left for 1 wk	5	43.9 ± 15.6^4-153	59.9 ± 32.2^4-153	104 ± 42^4-153	54.0 ± 17.2^4-153
Daily hAlb injections	3	61.4 ± 15.6^4-151	81.5 ± 14.0	143 ± 28^4-151	57.3 ± 4.3

Data: mean ± SD for (n) determinations.

Abbreviations: mTf, mouse transferrin; hTf, human transferrin; hAlb, human albumin.

P < .02.

P < .006.

P < .001 as compared with untreated homozygous mice.

P < .04 as compared with values in the appropriate 3-week–treated group.