Table 1. The Immunologic Barrier to... | American Society of Hematology

Table 1.

The Immunologic Barrier to Allogeneic BMT Can Be Overcome by Large Numbers of Donor Cells

BM Cells	H2^b → H2^b		H2^r → H2^r		H2^b → H2^r		H2^b → H2^k
0.02 × 10⁶	0%	n = 10	ND		0%	n = 5	ND
0.1 × 10⁶	80%	n = 10	ND		0%	n = 5	0%	n = 5
0.5 × 10⁶	89%	n = 28	80%	n = 15	0%	n = 24	1%	n = 60
2.5 × 10⁶	ND		ND		ND		60%	n = 10
5 × 10⁶	100%	n = 10	ND		35%	n = 34	100%	n = 10
25 × 10⁶	ND		ND		100%	n = 5	ND

BM Cells	H2^b → H2^b		H2^r → H2^r		H2^b → H2^r		H2^b → H2^k
0.02 × 10⁶	0%	n = 10	ND		0%	n = 5	ND
0.1 × 10⁶	80%	n = 10	ND		0%	n = 5	0%	n = 5
0.5 × 10⁶	89%	n = 28	80%	n = 15	0%	n = 24	1%	n = 60
2.5 × 10⁶	ND		ND		ND		60%	n = 10
5 × 10⁶	100%	n = 10	ND		35%	n = 34	100%	n = 10
25 × 10⁶	ND		ND		100%	n = 5	ND

Unfractionated BM cells were transplanted from C57.BL6 (H2^b) or B10.RIII (H2^r) donor mice into C57.BL6, B10.RIII, or B10.BR (H2^k) recipients after lethal irradiation with 10 Gy delivered in 2 doses. The percentage of mice surviving to day +60 posttransplant is shown.

Abbreviation: ND, not determined.

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