Analysis of Variant Genotypes of FcγRIIa, FcγRIIIa, and FcγRIIIb in a Healthy, Control Population
| AA . | CA . | ||||
|---|---|---|---|---|---|
| FcγRIIa FcγRIIIa | FcγRIIa FcγRIIIa | ||||
| HH | FF | 16 (40%) | HH | FF | 21 (37%) |
| HH | VF | 18 (45%) | HH | VF | 24 (43%) |
| HH | VV | 6 (15%) | HH | VV | 11 (20%) |
| HR | FF | 24 (38%) | HR | FF | 42 (52%) |
| HR | VF | 35 (54%) | HR | VF | 32 (39%) |
| HR | VV | 5 (8%) | HR | VV | 7 (9%) |
| RR | FF | 23 (50%) | RR | FF | 27 (63%) |
| RR | VF | 22 (48%) | RR | VF | 15 (35%) |
| RR | VV | 1 (2%) | RR | VV | 1 (2%) |
| χ2 = 5.97 P = NS | χ2 = 11.02 P = .078 | ||||
| FcγRIIa FcγRIIIb | FcγRIIa FcγRIIIb | ||||
| HH | NA1NA1 | 13 (32%) | HH | NA1NA1 | 9 (16%) |
| HH | NA1NA2 | 15 (38%) | HH | NA1NA2 | 29 (55%) |
| HH | NA2NA2 | 12 (30%) | HH | NA2NA2 | 16 (29%) |
| HR | NA1NA1 | 9 (14%) | HR | NA1NA1 | 8 (10%) |
| HR | NA1NA2 | 27 (42%) | HR | NA1NA2 | 41 (50%) |
| HR | NA2NA2 | 28 (44%) | HR | NA2NA2 | 32 (40%) |
| RR | NA1NA1 | 3 (7%) | RR | NA1NA1 | 3 (7%) |
| RR | NA1NA2 | 25 (57%) | RR | NA1NA2 | 15 (35%) |
| RR | NA2NA2 | 16 (36%) | RR | NA2NA2 | 24 (58%) |
| χ2 = 11.94 P = .053 | χ2 = 8.41 P = NS | ||||
| FcγRIIIa FcγRIIIb | FcγRIIIa FcγRIIIb | ||||
| FF | NA1NA1 | 13 (21%) | FF | NA1NA1 | 15 (17%) |
| FF | NA1NA2 | 26 (42%) | FF | NA1NA2 | 47 (53%) |
| FF | NA2NA2 | 23 (37%) | FF | NA2NA2 | 27 (30%) |
| VF | NA1NA1 | 10 (14%) | VF | NA1NA1 | 3 (4%) |
| VF | NA1NA2 | 34 (47%) | VF | NA1NA2 | 33 (46%) |
| VF | NA2NA2 | 30 (39%) | VF | NA2NA2 | 35 (50%) |
| VV | NA1NA1 | 2 (17%) | VV | NA1NA1 | 2 (11%) |
| VV | NA1NA2 | 7 (58%) | VV | NA1NA2 | 5 (28%) |
| VV | NA2NA2 | 3 (25%) | VV | NA2NA2 | 10 (61%) |
| χ2 = 2.39 P = NS | χ2 = 12.27 P = .046 | ||||
| AA . | CA . | ||||
|---|---|---|---|---|---|
| FcγRIIa FcγRIIIa | FcγRIIa FcγRIIIa | ||||
| HH | FF | 16 (40%) | HH | FF | 21 (37%) |
| HH | VF | 18 (45%) | HH | VF | 24 (43%) |
| HH | VV | 6 (15%) | HH | VV | 11 (20%) |
| HR | FF | 24 (38%) | HR | FF | 42 (52%) |
| HR | VF | 35 (54%) | HR | VF | 32 (39%) |
| HR | VV | 5 (8%) | HR | VV | 7 (9%) |
| RR | FF | 23 (50%) | RR | FF | 27 (63%) |
| RR | VF | 22 (48%) | RR | VF | 15 (35%) |
| RR | VV | 1 (2%) | RR | VV | 1 (2%) |
| χ2 = 5.97 P = NS | χ2 = 11.02 P = .078 | ||||
| FcγRIIa FcγRIIIb | FcγRIIa FcγRIIIb | ||||
| HH | NA1NA1 | 13 (32%) | HH | NA1NA1 | 9 (16%) |
| HH | NA1NA2 | 15 (38%) | HH | NA1NA2 | 29 (55%) |
| HH | NA2NA2 | 12 (30%) | HH | NA2NA2 | 16 (29%) |
| HR | NA1NA1 | 9 (14%) | HR | NA1NA1 | 8 (10%) |
| HR | NA1NA2 | 27 (42%) | HR | NA1NA2 | 41 (50%) |
| HR | NA2NA2 | 28 (44%) | HR | NA2NA2 | 32 (40%) |
| RR | NA1NA1 | 3 (7%) | RR | NA1NA1 | 3 (7%) |
| RR | NA1NA2 | 25 (57%) | RR | NA1NA2 | 15 (35%) |
| RR | NA2NA2 | 16 (36%) | RR | NA2NA2 | 24 (58%) |
| χ2 = 11.94 P = .053 | χ2 = 8.41 P = NS | ||||
| FcγRIIIa FcγRIIIb | FcγRIIIa FcγRIIIb | ||||
| FF | NA1NA1 | 13 (21%) | FF | NA1NA1 | 15 (17%) |
| FF | NA1NA2 | 26 (42%) | FF | NA1NA2 | 47 (53%) |
| FF | NA2NA2 | 23 (37%) | FF | NA2NA2 | 27 (30%) |
| VF | NA1NA1 | 10 (14%) | VF | NA1NA1 | 3 (4%) |
| VF | NA1NA2 | 34 (47%) | VF | NA1NA2 | 33 (46%) |
| VF | NA2NA2 | 30 (39%) | VF | NA2NA2 | 35 (50%) |
| VV | NA1NA1 | 2 (17%) | VV | NA1NA1 | 2 (11%) |
| VV | NA1NA2 | 7 (58%) | VV | NA1NA2 | 5 (28%) |
| VV | NA2NA2 | 3 (25%) | VV | NA2NA2 | 10 (61%) |
| χ2 = 2.39 P = NS | χ2 = 12.27 P = .046 | ||||
A 3 × 3 χ2 test with 4 degrees of freedom was performed for each 2-locus comparison (ie, HH, HR, RR and VV, VF, FF).P values are corrected by a factor of 3, reflecting the exploratory comparison of 3 separate loci. Individuals lacking the FcγRIIIb gene are not included.
Abbreviation: NS, not significant.