Relationship Between Spleen Size and Hematocrit and Reticulocyte Values in Mice Lacking NF-E2
| Animal (No.) . | Spleen Weight (mg) . | Presplenectomy HCT (%) . | Presplenectomy RETIC (%) . |
|---|---|---|---|
| 53 | 256.4 | 49 | 6.0 |
| 21 | 262.9 | 45 | 5.0 |
| 8 | 295.2 | ND | 12.8 |
| 1 | 362.2 | ND | 10.0 |
| 12 | 383.5 | 43 | 24.7 |
| 6 | 392.3 | 43 | 16.4 |
| 58 | 399.7 | 40 | 7.6 |
| 19 | 423.0 | 35 | 12.7 |
| Animal (No.) . | Spleen Weight (mg) . | Presplenectomy HCT (%) . | Presplenectomy RETIC (%) . |
|---|---|---|---|
| 53 | 256.4 | 49 | 6.0 |
| 21 | 262.9 | 45 | 5.0 |
| 8 | 295.2 | ND | 12.8 |
| 1 | 362.2 | ND | 10.0 |
| 12 | 383.5 | 43 | 24.7 |
| 6 | 392.3 | 43 | 16.4 |
| 58 | 399.7 | 40 | 7.6 |
| 19 | 423.0 | 35 | 12.7 |
Before splenectomy, blood was drawn from NF-E2 knockout mice for hematocrit (HCT) and reticulocyte (RETIC) determinations. The spleens were weighed after removal. Spleen weight in normal controls averaged 113 mg. Regression co-efficients, calculated using the Pearson product moment correlation, were −.841 (P = .036) between spleen weight and HCT and .522 (P = .184) between spleen weight and RETIC.
Abbreviation: ND, not determined.