Immunological Recovery of Leukemia Patients Treated With Allo-BMT: Laboratory Findings at 3 and 12 Months After Transplantation
Patient . | Age at BMT (yrs) . | No. of Lymphocytes* . | No. of CD3+ . | No. of CD4+ . | No. of CD8+ . | No. of CD16+/56+ (CD3−) . | No. of CD20+ . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3 . | 12 . | 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | ||
I† | |||||||||||||
UPN 272 | 11 | 1.05 | 1.12 | 0.89 | 0.71 | 0.09 | 0.15 | 0.81 | 0.55 | 0.03 | 0.10 | 0.12 | 0.29 |
UPN 273‡ | 12 | 0.50 | 2-153 | 0.20 | — | 0.13 | — | 0.11 | — | 0.30 | — | 0.03 | — |
UPN 279 | 10 | 1.05 | 2.76 | 0.15 | 1.35 | 0.05 | 0.97 | 0.13 | 0.41 | 0.38 | 0.25 | 0.39 | 1.0 |
II | |||||||||||||
UPN 298 | 7 | 0.68 | 5.25 | 0.51 | 4.25 | 0.03 | 0.79 | 0.48 | 3.30 | 0.20 | 0.47 | 0.007 | 0.21 |
UPN 301 | 2 | 1.88 | 3.07 | 1.39 | 2.18 | 0.76 | 1.35 | 0.76 | 0.68 | 0.47 | 0.06 | 0.17 | 0.65 |
UPN 329 | 2 | 1.34 | 2-153 | 0.48 | — | 0.20 | — | 0.29 | — | 0.34 | — | 0.25 | — |
III | |||||||||||||
UPN 274 | 6 | 0.62 | 2-153 | 0.56 | — | 0.09 | — | 0.47 | — | 0.11 | — | 0.006 | — |
UPN 275 | 11 | 1.87 | 2.96 | 1.46 | 2.16 | 0.19 | 0.59 | 1.25 | 1.6 | 0.32 | 0.47 | 0.08 | 0.62 |
UPN 276 | 14 | 1.36 | 2.93 | 1.09 | 2.08 | 0.39 | 0.85 | 0.71 | 1.29 | 0.20 | 0.41 | 0.09 | 0.70 |
UPN 285 | 10 | 1.03 | 1.96 | 0.73 | 0.80 | 0.22 | 0.53 | 0.58 | 0.55 | 0.27 | 0.31 | 0.02 | 0.80 |
UPN 291 | 7 | 1.72 | 3.50 | 1.31 | 2.21 | 0.24 | 0.98 | 1.07 | 1.23 | 0.21 | 0.25 | 0.21 | 0.95 |
UPN 296 | 15 | 0.83 | 0.43 | 0.37 | 0.23 | 0.12 | 0.15 | 0.21 | 0.09 | 0.18 | 0.09 | 0.22 | 0.23 |
Reference2-155 | 2-4 | 3.7 (2.3-5.4) | 2.1 (1.2-3.7) | 1.3 (0.7-2.4) | 0.7 (0.4-1.1) | 0.5 (0.2-0.7) | 0.8 (0.4-1.4) | ||||||
5-9 | 2.6 (1.7-3.5) | 1.8 (1.0-2.6) | 1.0 (0.6-1.5) | 0.6 (0.3-1.0) | 0.2 (0.1-0.5) | 0.3 (0.2-0.7) | |||||||
10-14 | 2.4 (1.6-3.1) | 1.6 (0.9-2.4) | 0.9 (0.6-1.6) | 0.5 (0.2-0.9) | 0.3 (0.1-0.5) | 0.3 (0.1-0.6) | |||||||
15-70 | 1.9 (1.3-3.0) | 1.3 (0.8-1.9) | 0.8 (0.5-1.2) | 0.4 (0.3-0.8) | 0.3 (0.1-0.6) | 0.3 (0.1-0.6) |
Patient . | Age at BMT (yrs) . | No. of Lymphocytes* . | No. of CD3+ . | No. of CD4+ . | No. of CD8+ . | No. of CD16+/56+ (CD3−) . | No. of CD20+ . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3 . | 12 . | 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | ||
I† | |||||||||||||
UPN 272 | 11 | 1.05 | 1.12 | 0.89 | 0.71 | 0.09 | 0.15 | 0.81 | 0.55 | 0.03 | 0.10 | 0.12 | 0.29 |
UPN 273‡ | 12 | 0.50 | 2-153 | 0.20 | — | 0.13 | — | 0.11 | — | 0.30 | — | 0.03 | — |
UPN 279 | 10 | 1.05 | 2.76 | 0.15 | 1.35 | 0.05 | 0.97 | 0.13 | 0.41 | 0.38 | 0.25 | 0.39 | 1.0 |
II | |||||||||||||
UPN 298 | 7 | 0.68 | 5.25 | 0.51 | 4.25 | 0.03 | 0.79 | 0.48 | 3.30 | 0.20 | 0.47 | 0.007 | 0.21 |
UPN 301 | 2 | 1.88 | 3.07 | 1.39 | 2.18 | 0.76 | 1.35 | 0.76 | 0.68 | 0.47 | 0.06 | 0.17 | 0.65 |
UPN 329 | 2 | 1.34 | 2-153 | 0.48 | — | 0.20 | — | 0.29 | — | 0.34 | — | 0.25 | — |
III | |||||||||||||
UPN 274 | 6 | 0.62 | 2-153 | 0.56 | — | 0.09 | — | 0.47 | — | 0.11 | — | 0.006 | — |
UPN 275 | 11 | 1.87 | 2.96 | 1.46 | 2.16 | 0.19 | 0.59 | 1.25 | 1.6 | 0.32 | 0.47 | 0.08 | 0.62 |
UPN 276 | 14 | 1.36 | 2.93 | 1.09 | 2.08 | 0.39 | 0.85 | 0.71 | 1.29 | 0.20 | 0.41 | 0.09 | 0.70 |
UPN 285 | 10 | 1.03 | 1.96 | 0.73 | 0.80 | 0.22 | 0.53 | 0.58 | 0.55 | 0.27 | 0.31 | 0.02 | 0.80 |
UPN 291 | 7 | 1.72 | 3.50 | 1.31 | 2.21 | 0.24 | 0.98 | 1.07 | 1.23 | 0.21 | 0.25 | 0.21 | 0.95 |
UPN 296 | 15 | 0.83 | 0.43 | 0.37 | 0.23 | 0.12 | 0.15 | 0.21 | 0.09 | 0.18 | 0.09 | 0.22 | 0.23 |
Reference2-155 | 2-4 | 3.7 (2.3-5.4) | 2.1 (1.2-3.7) | 1.3 (0.7-2.4) | 0.7 (0.4-1.1) | 0.5 (0.2-0.7) | 0.8 (0.4-1.4) | ||||||
5-9 | 2.6 (1.7-3.5) | 1.8 (1.0-2.6) | 1.0 (0.6-1.5) | 0.6 (0.3-1.0) | 0.2 (0.1-0.5) | 0.3 (0.2-0.7) | |||||||
10-14 | 2.4 (1.6-3.1) | 1.6 (0.9-2.4) | 0.9 (0.6-1.6) | 0.5 (0.2-0.9) | 0.3 (0.1-0.5) | 0.3 (0.1-0.6) | |||||||
15-70 | 1.9 (1.3-3.0) | 1.3 (0.8-1.9) | 0.8 (0.5-1.2) | 0.4 (0.3-0.8) | 0.3 (0.1-0.6) | 0.3 (0.1-0.6) |
Absolute numbers: ×103 cells/μL peripheral blood.
Transplantation groups as mentioned in Table 1.
Analysis at 68 days post-BMT; other time-points were not available.
Recipient died before second analysis at 1 year after transplantation (UPN 273, UPN 329, and UPN 274).
Age-matched reference values according to Comans-Bitter et al34; values are the median, with ranges from 5 to 95 percentiles in parentheses.