Absolute Numbers of CD45RA+ and CD45RO+ T Cells in CD4+ and CD8+ T-Cell Subsets at 3 and 12 Months After Transplantation
| Recipient . | Age at BMT (yrs) . | No. of CD4 CD45RA+3-150 . | No. of CD4 CD45RO+ . | No. of CD8 CD45RA+ . | No. of CD8 CD45RO+ . | ||||
|---|---|---|---|---|---|---|---|---|---|
| 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | ||
| I3-151 | |||||||||
| UPN 272 | 11 | 0.004 | 0.03 | 0.13 | 0.13 | 0.14 | 0.29 | 0.68 | 0.42 |
| UPN 273 | 12 | ND | 3-152 | ND | — | ND | — | ND | — |
| UPN 279 | 10 | 0.007 | 0.59 | 0.05 | 0.38 | 0.08 | 0.31 | 0.05 | 0.13 |
| II | |||||||||
| UPN 298 | 7 | 0.004 | 0.08 | 0.03 | 0.73 | 0.18 | 1.60 | 0.37 | 2.40 |
| UPN 301 | 2 | 0.13 | 1.08 | 0.72 | 0.24 | 0.23 | 0.62 | 0.64 | 0.05 |
| UPN 329 | 2 | 0.05 | 3-152 | 0.18 | — | 0.15 | — | 0.22 | — |
| III | |||||||||
| UPN 274 | 6 | 0.01 | 3-152 | 0.08 | — | 0.23 | — | 0.21 | — |
| UPN 275 | 11 | 0.03 | 0.19 | 0.14 | 0.42 | 0.7 | 1.14 | 0.51 | 0.80 |
| UPN 276 | 14 | 0.03 | 0.28 | 0.37 | 0.65 | 0.55 | 1.11 | 0.27 | 0.46 |
| UPN 285 | 10 | 0.04 | 0.10 | 0.21 | 0.44 | 0.31 | 0.38 | 0.30 | 0.19 |
| UPN 291 | 7 | 0.06 | 0.46 | 0.20 | 0.51 | 0.31 | 0.50 | 0.92 | 0.76 |
| UPN 296 | 15 | 0.01 | 0.04 | 0.10 | 0.13 | 0.12 | 0.07 | 0.11 | 0.02 |
| Reference3-153 | 1-6 | 1.14 (0.66-1.39) | 0.6 (0.4-1.5) | 1.0 (0.6-1.3) | 0.1 (0.1-0.5) | ||||
| 7-17 | 0.49 (0.39-0.74) | ||||||||
| 18-70 | 0.32 (0.22-0.54) | 0.3 (0.1-0.8) | 0.4 (0.1-0.8) | 0.2 (0.2-0.4) | |||||
| Recipient . | Age at BMT (yrs) . | No. of CD4 CD45RA+3-150 . | No. of CD4 CD45RO+ . | No. of CD8 CD45RA+ . | No. of CD8 CD45RO+ . | ||||
|---|---|---|---|---|---|---|---|---|---|
| 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | 3 . | 12 . | ||
| I3-151 | |||||||||
| UPN 272 | 11 | 0.004 | 0.03 | 0.13 | 0.13 | 0.14 | 0.29 | 0.68 | 0.42 |
| UPN 273 | 12 | ND | 3-152 | ND | — | ND | — | ND | — |
| UPN 279 | 10 | 0.007 | 0.59 | 0.05 | 0.38 | 0.08 | 0.31 | 0.05 | 0.13 |
| II | |||||||||
| UPN 298 | 7 | 0.004 | 0.08 | 0.03 | 0.73 | 0.18 | 1.60 | 0.37 | 2.40 |
| UPN 301 | 2 | 0.13 | 1.08 | 0.72 | 0.24 | 0.23 | 0.62 | 0.64 | 0.05 |
| UPN 329 | 2 | 0.05 | 3-152 | 0.18 | — | 0.15 | — | 0.22 | — |
| III | |||||||||
| UPN 274 | 6 | 0.01 | 3-152 | 0.08 | — | 0.23 | — | 0.21 | — |
| UPN 275 | 11 | 0.03 | 0.19 | 0.14 | 0.42 | 0.7 | 1.14 | 0.51 | 0.80 |
| UPN 276 | 14 | 0.03 | 0.28 | 0.37 | 0.65 | 0.55 | 1.11 | 0.27 | 0.46 |
| UPN 285 | 10 | 0.04 | 0.10 | 0.21 | 0.44 | 0.31 | 0.38 | 0.30 | 0.19 |
| UPN 291 | 7 | 0.06 | 0.46 | 0.20 | 0.51 | 0.31 | 0.50 | 0.92 | 0.76 |
| UPN 296 | 15 | 0.01 | 0.04 | 0.10 | 0.13 | 0.12 | 0.07 | 0.11 | 0.02 |
| Reference3-153 | 1-6 | 1.14 (0.66-1.39) | 0.6 (0.4-1.5) | 1.0 (0.6-1.3) | 0.1 (0.1-0.5) | ||||
| 7-17 | 0.49 (0.39-0.74) | ||||||||
| 18-70 | 0.32 (0.22-0.54) | 0.3 (0.1-0.8) | 0.4 (0.1-0.8) | 0.2 (0.2-0.4) | |||||
The number of CD45RA+ and CD45RO+ cells within the CD4+ and CD8+ T-cell subsets was determined after staining with anti-CD45RA and anti-CD45RO MoAbs; RA+RO+ double-positive T cells were calculated as well.
Abbreviation: ND, not determined.
Absolute numbers of cells: ×103/μL peripheral blood.
Transplantation groups as mentioned in Table 1.
Patient died before second analysis.
Age-matched CD4+CD45RA+ reference values,35 with ranges from 25 to 75 percentiles in parentheses. Reference values for CD4+CD45RO+ T cells and for CD45RA+- and CD45RO+-CD8+ T cells were only available for children of 1 year old and for adults; values are the median, followed by minimal and maximal absolute counts in parentheses.36