Table 2. Effects of HU, CLT, Mg, and CLT... | American Society of Hematology

Table 2.

Effects of HU, CLT, Mg, and CLT + Mg Treatments Under Ambient and Hypoxic Conditions on Erythrocyte Gardos Channel Activity, K Content, and D₅₀ of SAD Mice

	Untreated (n = 6)	HU (n = 6)	CLT (n = 5)	Mg (n = 5)	CLT + Mg (n = 6)
Gardos channel activity (mmol/L cell × min)
Baseline	12.6 ± 0.7	11.7 ± 1.2	11.8 ± 0.9	10.8 ± 1.3	11.4 ± 0.9
3 wks	11.6 ± 1.2	12.4 ± 0.6	3.2 ± 0.1^*	11.9 ± 1.8	2.7 ± 1.3^*
After 48 h of hypoxia	12.3 ± 1.2	12.3 ± 1.2	4.4 ± 0.4^*	10.4 ± 0.7	3.1 ± 0.6^*
Erythrocyte K content (mmol/kg Hb)
Baseline	350 ± 12	330 ± 8.4	346 ± 12	340 ± 10	358 ± 20
3 wks	348 ± 18.3	394 ± 10.1^*	401 ± 10.1^*	390 ± 12^*	410 ± 3.2^*
After 48 h of hypoxia	310 ± 9.7^*,^†	370 ± 11.3^*,^‡	398 ± 8.4^*	350 ± 4.7^†	407 ± 12^*
D₅₀
Baseline	1.099 ± 0.002	1.101 ± 0.002	1.097 ± 0.001	1.097 ± 0.001	1.102 ± 0.002
3 wks	—	1.098 ± 0.003^2-153	1.092 ± 0.001^2-155	1.093 ± 0.001^2-153	1.095 ± 0.002^*
After 48 h of hypoxia	1.107 ± 0.004^2-153	1.101 ± 0.004	1.097 ± 0.001^†	1.096 ± 0.002^†	1.096 ± 0.005^2-153

	Untreated (n = 6)	HU (n = 6)	CLT (n = 5)	Mg (n = 5)	CLT + Mg (n = 6)
Gardos channel activity (mmol/L cell × min)
Baseline	12.6 ± 0.7	11.7 ± 1.2	11.8 ± 0.9	10.8 ± 1.3	11.4 ± 0.9
3 wks	11.6 ± 1.2	12.4 ± 0.6	3.2 ± 0.1^*	11.9 ± 1.8	2.7 ± 1.3^*
After 48 h of hypoxia	12.3 ± 1.2	12.3 ± 1.2	4.4 ± 0.4^*	10.4 ± 0.7	3.1 ± 0.6^*
Erythrocyte K content (mmol/kg Hb)
Baseline	350 ± 12	330 ± 8.4	346 ± 12	340 ± 10	358 ± 20
3 wks	348 ± 18.3	394 ± 10.1^*	401 ± 10.1^*	390 ± 12^*	410 ± 3.2^*
After 48 h of hypoxia	310 ± 9.7^*,^†	370 ± 11.3^*,^‡	398 ± 8.4^*	350 ± 4.7^†	407 ± 12^*
D₅₀
Baseline	1.099 ± 0.002	1.101 ± 0.002	1.097 ± 0.001	1.097 ± 0.001	1.102 ± 0.002
3 wks	—	1.098 ± 0.003^2-153	1.092 ± 0.001^2-155	1.093 ± 0.001^2-153	1.095 ± 0.002^*
After 48 h of hypoxia	1.107 ± 0.004^2-153	1.101 ± 0.004	1.097 ± 0.001^†	1.096 ± 0.002^†	1.096 ± 0.005^2-153

Data are expressed as the means ± SD.

P < .02 compared with baseline.

†

P < .02 compared with after 3 weeks of therapy.

‡

P < .05 compared with after 3 weeks of therapy.

F2-153

P < .05 compared with baseline.

F2-155

P < .005 compared with baseline.

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