Number of circulating microparticles on admission in patients with meningococcal sepsis and healthy volunteers
| Marker . | Patients (n = 7) . | Volunteers (n = 5) . | Nx/Nt* . | P† . |
|---|---|---|---|---|
| CD4 (THcells)‡ | 6.1 (0.0-65)1-153 | 19.3 (2.65-47.9) | 1/7 | .432 |
| CD8 (TS cells) | ND1-154 | ND | ND | ND |
| CD14 (monocytes) | 15.3 (0.0-735) | 7.7 (0.0-16.1) | 3/7 | .315 |
| CD20 (B cells) | 10.0 (0.0-89) | 0.0 (0.0-6.6) | 5/7 | .202 |
| CD61 (platelets) | 597 (101-1692) | 41 (16-80) | 7/7 | .004 |
| CD62E (endothelial cells) | 61 (8.0-244) | 18 (8.0-40) | 5/7 | .318 |
| CD66b (granulocytes) | 234 (29-294) | 1.3 (0.0-5.5) | 7/7 | .008 |
| Glycophorin A (erythrocytes) | 72 (42-191) | 51 (22-95) | 1/7 | .993 |
| Marker . | Patients (n = 7) . | Volunteers (n = 5) . | Nx/Nt* . | P† . |
|---|---|---|---|---|
| CD4 (THcells)‡ | 6.1 (0.0-65)1-153 | 19.3 (2.65-47.9) | 1/7 | .432 |
| CD8 (TS cells) | ND1-154 | ND | ND | ND |
| CD14 (monocytes) | 15.3 (0.0-735) | 7.7 (0.0-16.1) | 3/7 | .315 |
| CD20 (B cells) | 10.0 (0.0-89) | 0.0 (0.0-6.6) | 5/7 | .202 |
| CD61 (platelets) | 597 (101-1692) | 41 (16-80) | 7/7 | .004 |
| CD62E (endothelial cells) | 61 (8.0-244) | 18 (8.0-40) | 5/7 | .318 |
| CD66b (granulocytes) | 234 (29-294) | 1.3 (0.0-5.5) | 7/7 | .008 |
| Glycophorin A (erythrocytes) | 72 (42-191) | 51 (22-95) | 1/7 | .993 |
Nx indicates the number of patient plasma samples that contained more microparticles (for the indicated CD marker) than the highest number found in volunteers; Nt indicates the total number of patient samples tested.
Patients versus volunteers (Mann-Whitney test).
Microparticles were isolated, labeled, and analyzed, and their numbers were calculated as described in “Materials and Methods.”
Data are expressed as median (range) and represent number ×106/L plasma.
Not detectable.