Thrombin generation in plasma of patients with meningococcal sepsis in vivo and by microparticles in vitro
| Time (h)* . | In Vivo . | In Vitro . | ||||
|---|---|---|---|---|---|---|
| F1+2 (nmol/L) . | Nx/Nt† . | P‡ . | TGT (OD 405 nm)2-153 . | Nx/Nt2-154 . | P‡ . | |
| 0 | 5.5 (4.1-10)# | 7/7 | .004 | 0.105 (0.088-0.149)# | 7/7 | .003 |
| 4 | 4.1 (3.4-20) | 5/5 | .009 | 0.080 (0.070-0.132) | 5/5 | .009 |
| 10 | 5.5 (2.1-8.6) | 4/5 | .026 | 0.084 (0.068-0.106) | 5/5 | .009 |
| 16 | 3.8 (2.2-12.7) | 4/5 | .016 | 0.100 (0.090-0.116) | 5/5 | .009 |
| 24 | 4.2 (2.4-4.9) | 4/5 | .016 | 0.070 (0.055-0.079) | 3/5 | .117 |
| 36 | 3.2 (1.4-3.8) | 4/5 | .140 | 0.078 (0.067-0.142) | 4/4 | .014 |
| Volunteers | 2.1 (1.1-2.8) | — | — | 0.057 (0.044-0.063) | — | — |
| Time (h)* . | In Vivo . | In Vitro . | ||||
|---|---|---|---|---|---|---|
| F1+2 (nmol/L) . | Nx/Nt† . | P‡ . | TGT (OD 405 nm)2-153 . | Nx/Nt2-154 . | P‡ . | |
| 0 | 5.5 (4.1-10)# | 7/7 | .004 | 0.105 (0.088-0.149)# | 7/7 | .003 |
| 4 | 4.1 (3.4-20) | 5/5 | .009 | 0.080 (0.070-0.132) | 5/5 | .009 |
| 10 | 5.5 (2.1-8.6) | 4/5 | .026 | 0.084 (0.068-0.106) | 5/5 | .009 |
| 16 | 3.8 (2.2-12.7) | 4/5 | .016 | 0.100 (0.090-0.116) | 5/5 | .009 |
| 24 | 4.2 (2.4-4.9) | 4/5 | .016 | 0.070 (0.055-0.079) | 3/5 | .117 |
| 36 | 3.2 (1.4-3.8) | 4/5 | .140 | 0.078 (0.067-0.142) | 4/4 | .014 |
| Volunteers | 2.1 (1.1-2.8) | — | — | 0.057 (0.044-0.063) | — | — |
Time after admission (t = 0).
Nx indicates the number of patient plasma samples that contained a higher concentration of F1+2 than the highest concentration found in healthy volunteers; Nt indicates the total number of patient samples tested.
Patients versus volunteers (Mann-Whitney test).
TGT indicates thrombin generation test.
Nx indicates the number of patient microparticle fractions that generated more thrombin than the highest of the volunteer samples tested.
#Median (range).