Table 1.

Clinical features and hematologic responses

Low-Dose GroupHigh-Dose Group
TFPI Placebo PTFPI Placebo P
Peak temperature (°C) 38.6 ± 0.2  38.8 ± 0.2  NS  38.3 ± 0.2 38.2 ± 0.2  NS  
Time to temperature peak (h) 3.6 ± 0.2  3.6 ± 0.2  NS  3.9 ± 0.2 3.9 ± 0.4  NS  
Heart rate (peak, bpm)  107 ± 3.9 110 ± 3.0  NS  102 ± 6.4  99 ± 3.0  NS 
Systolic blood pressure (nadir, mm Hg)  103 ± 5.1 104 ± 2.0  NS  105 ± 2.7  106 ± 2.9  NS 
White blood count (×109/L)  
 Nadir 2.5 ± 0.1  2.1 ± 0.2  NS  2.0 ± 0.2 1.9 ± 0.1  NS  
 Peak  14.1 ± 0.7 14.6 ± 1.4  NS  13.9 ± 0.8  13.1 ± 1.3 NS 
Low-Dose GroupHigh-Dose Group
TFPI Placebo PTFPI Placebo P
Peak temperature (°C) 38.6 ± 0.2  38.8 ± 0.2  NS  38.3 ± 0.2 38.2 ± 0.2  NS  
Time to temperature peak (h) 3.6 ± 0.2  3.6 ± 0.2  NS  3.9 ± 0.2 3.9 ± 0.4  NS  
Heart rate (peak, bpm)  107 ± 3.9 110 ± 3.0  NS  102 ± 6.4  99 ± 3.0  NS 
Systolic blood pressure (nadir, mm Hg)  103 ± 5.1 104 ± 2.0  NS  105 ± 2.7  106 ± 2.9  NS 
White blood count (×109/L)  
 Nadir 2.5 ± 0.1  2.1 ± 0.2  NS  2.0 ± 0.2 1.9 ± 0.1  NS  
 Peak  14.1 ± 0.7 14.6 ± 1.4  NS  13.9 ± 0.8  13.1 ± 1.3 NS 
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