Leucocyte recruitment to virus infected meninges is unimpaired in E/P-sel −/− and E-sel −/− mice
| Days pi . | Mice . | Cells ×103/mL CSF . | % CD8+ . | % Mac-1+ . |
|---|---|---|---|---|
| 6 | E/P-sel −/− | 0.9 (0.7-1.3) | ||
| E-sel −/− | 1.2 (0.0-2.3) | |||
| Wild-type | 0.7 (0.0-2.0) | |||
| 7 | E/P-sel −/− | 5.6 (3.6-7.5) | 50 (38-65) | 41 (19-44) |
| E-sel −/− | 6.9 (5.0-9.5) | 57 (43-68) | 33 (19-45) | |
| Wild-type | 4.4 (2.0-8.4) | 51 (38-66) | 34 (25-40) |
| Days pi . | Mice . | Cells ×103/mL CSF . | % CD8+ . | % Mac-1+ . |
|---|---|---|---|---|
| 6 | E/P-sel −/− | 0.9 (0.7-1.3) | ||
| E-sel −/− | 1.2 (0.0-2.3) | |||
| Wild-type | 0.7 (0.0-2.0) | |||
| 7 | E/P-sel −/− | 5.6 (3.6-7.5) | 50 (38-65) | 41 (19-44) |
| E-sel −/− | 6.9 (5.0-9.5) | 57 (43-68) | 33 (19-45) | |
| Wild-type | 4.4 (2.0-8.4) | 51 (38-66) | 34 (25-40) |
Mice were infected with 103 LD50 of LCMV intracerebrally and on the indicated days CSF was harvested, exudate cells were counted, and the composition determined by flow cytometry. Groups consisted of 4 to 6 mice; medians and ranges are presented.
pi = after infection; CSF = cerecrospinal fluid; LCMV = lymphocytic choriomeningitis virus.